About: Extremely Reduced Levels of Heterozygosity in the Vertebrate Pathogen Encephalitozoon cuniculi

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About: Extremely Reduced Levels of Heterozygosity in the Vertebrate Pathogen Encephalitozoon cuniculi Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The genomes of microsporidia in the genus Encephalitozoon have been extensively studied for their minimalistic features, but they have seldom been used to investigate basic characteristics of the biology of these organisms, such as their ploidy or their mode of reproduction. In the present study, we aimed to tackle this issue by mapping Illumina sequence reads against the genomes of four strains of E. cuniculi. This approach, combined with more conventional molecular biology techniques, resulted in the identification of heterozygosity in all strains investigated, a typical signature of a diploid nuclear state. In sharp contrast with similar studies recently performed on a distant microsporidian lineage (Nematocida spp.), the level of heterozygosity that we identified across the E. cuniculi genomes was found to be extremely low. This reductive intraindividual genetic variation could result from the long-term propagation of these strains under laboratory conditions, but we propose that it could also reflect an intrinsic capacity of these vertebrate pathogens to self-reproduce. The genomes of microsporidia in the genus Encephalitozoon have been extensively studied for their minimalistic features, but they have seldom been used to investigate basic characteristics of the biology of these organisms, such as their ploidy or their mode of reproduction. In the present study, we aimed to tackle this issue by mapping Illumina sequence reads against the genomes of four strains of E. cuniculi. This approach, combined with more conventional molecular biology techniques, resulted in the identification of heterozygosity in all strains investigated, a typical signature of a diploid nuclear state. In sharp contrast with similar studies recently performed on a distant microsporidian lineage (Nematocida spp.), the level of heterozygosity that we identified across the E. cuniculi genomes was found to be extremely low. This reductive intraindividual genetic variation could result from the long-term propagation of these strains under laboratory conditions, but we propose that it could also reflect an intrinsic capacity of these vertebrate pathogens to self-reproduce. (en)
Title	Extremely Reduced Levels of Heterozygosity in the Vertebrate Pathogen Encephalitozoon cuniculi Extremely Reduced Levels of Heterozygosity in the Vertebrate Pathogen Encephalitozoon cuniculi (en)
skos:prefLabel	Extremely Reduced Levels of Heterozygosity in the Vertebrate Pathogen Encephalitozoon cuniculi Extremely Reduced Levels of Heterozygosity in the Vertebrate Pathogen Encephalitozoon cuniculi (en)
skos:notation	RIV/60077344:_____/13:00397476!RIV14-AV0-60077344
http://linked.open...avai/riv/aktivita	I P
http://linked.open...avai/riv/aktivity	I, P(GAP505/11/1163)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Sak, Bohumil Kváč, Martin
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	74455
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/13:00397476
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	intracellular parasites; microsporidian genome; sexual reproduction; clonal diploids (en)
http://linked.open.../riv/klicoveSlovo	clonal diploids intracellular parasites microsporidian genome sexual reproduction
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[A5C89EF4663D]
http://linked.open...i/riv/nazevZdroje	Eukaryotic Cell
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Anti-inflammatory activity of extracts isolated from selected Indonesian plants and their effect on opportunistic parasitoses
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	12
http://linked.open...iv/tvurceVysledku	Kváč, Martin Sak, Bohumil Corradi, N. Farinelli, L. Selman, M. Weiss, L. M.
http://linked.open...ain/vavai/riv/wos	000316805100003
issn	1535-9778
number of pages	7 (xsd:int)
http://bibframe.org/vocab/doi	10.1128/EC.00307-12

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