About: Decreased hepatotoxic bile acid composition and altered synthesis in progressive human nonalcoholic fatty liver disease

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About: Decreased hepatotoxic bile acid composition and altered synthesis in progressive human nonalcoholic fatty liver disease Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Nonalcoholic fatty liver disease (NAFLD) is a prevalent form of chronic liver disease characterized by the pathophysiological progression from simple steatosis to nonalcoholic steatohepatitis (NASH). The hypothesis of this study is that the classical’ (neutral) and alternative’ (acidic) BA synthesis pathways are altered together with hepatic BA composition during progression of human NAFLD. This study employed the use of transcriptomic andmetabolomic assays to study the hepatic toxicologic BA profile in progressive human NAFLD. Individual human liver samples diagnosed as normal, steatosis, and NASH were utilized in the assays. The transcriptomic analysis of 70 BA genes revealed an enrichment of downregulated BA metabolism and transcription factor/receptor genes in livers diagnosed as NASH. Increased mRNA expression of BAAT and CYP7B1was observed in contrast to decreased CYP8B1 expression in NASH samples. The BA metabolomic profile of NASH livers exhibited an increase in taurine together with elevated levels of conjugated BA species, taurocholic acid (TCA) and taurodeoxycholic acid (TDCA). Nonalcoholic fatty liver disease (NAFLD) is a prevalent form of chronic liver disease characterized by the pathophysiological progression from simple steatosis to nonalcoholic steatohepatitis (NASH). The hypothesis of this study is that the classical’ (neutral) and alternative’ (acidic) BA synthesis pathways are altered together with hepatic BA composition during progression of human NAFLD. This study employed the use of transcriptomic andmetabolomic assays to study the hepatic toxicologic BA profile in progressive human NAFLD. Individual human liver samples diagnosed as normal, steatosis, and NASH were utilized in the assays. The transcriptomic analysis of 70 BA genes revealed an enrichment of downregulated BA metabolism and transcription factor/receptor genes in livers diagnosed as NASH. Increased mRNA expression of BAAT and CYP7B1was observed in contrast to decreased CYP8B1 expression in NASH samples. The BA metabolomic profile of NASH livers exhibited an increase in taurine together with elevated levels of conjugated BA species, taurocholic acid (TCA) and taurodeoxycholic acid (TDCA). (en)
Title	Decreased hepatotoxic bile acid composition and altered synthesis in progressive human nonalcoholic fatty liver disease Decreased hepatotoxic bile acid composition and altered synthesis in progressive human nonalcoholic fatty liver disease (en)
skos:prefLabel	Decreased hepatotoxic bile acid composition and altered synthesis in progressive human nonalcoholic fatty liver disease Decreased hepatotoxic bile acid composition and altered synthesis in progressive human nonalcoholic fatty liver disease (en)
skos:notation	RIV/60077344:_____/13:00393133!RIV14-AV0-60077344
http://linked.open...avai/riv/aktivita	I Z
http://linked.open...avai/riv/aktivity	I, Z(AV0Z50510513)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Novák, Petr
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	68117
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/13:00393133
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Bile Acids; Liver; Metabolomics (en)
http://linked.open.../riv/klicoveSlovo	Bile Acids Metabolomics Liver
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[FAFD3618CD2A]
http://linked.open...i/riv/nazevZdroje	Toxicology and Applied Pharmacology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	268
http://linked.open...iv/tvurceVysledku	Cherrington, N. J. Lake, A. D. Novák, Petr Lu, Z. Aranibar, N. Lehman-McKeeman, L. D. Reily, M. D. Robertson, D. Shipkova, P.
http://linked.open...ain/vavai/riv/wos	000316978700005
http://linked.open...n/vavai/riv/zamer	Výzkum struktury genetické informace rostlin a jejich patogenů na molekulární úrovni, indukce a analýza cílených změn genomu a plastomu a studium fotosyntetických procesů a projevů dědičnosti v interakci s prostředím a patogeny
issn	0041-008X
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.taap.2013.01.022

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