About: Make It, Take It, or Leave It: Heme Metabolism of Parasites

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Heme and other tetrapyrroles, often called “the colors of life, belong to the most important molecules of almost all extant organisms. They are synthesized by a common multistep pathway that is highly conserved throughout the tree of life [1]. One of the tetrapyrrole products is chlorophyll, the green pigment of plants and other phototrophs, which captures the energy of the sun. Vitamin B12, the most complex tetrapyrrole, is involved in DNA synthesis and energy metabolism [2]. The major product of tetrapyrrole biosynthesis in non-photosynthetic organisms is heme, an iron-coordinated porphyrin with the capacity to transfer electrons and bind diatomic gases. Here we summarize the current understanding of different aspects of heme metabolism in parasitic eukaryotes, including the synthesis and uptake of heme and its detoxification. A differential need for heme in distinct parasitic groups and the suitability of heme metabolism as a drug target for treating parasite-borne diseases are also discussed. First, however, let us review the functions of heme in various cellular processes. Heme and other tetrapyrroles, often called “the colors of life, belong to the most important molecules of almost all extant organisms. They are synthesized by a common multistep pathway that is highly conserved throughout the tree of life [1]. One of the tetrapyrrole products is chlorophyll, the green pigment of plants and other phototrophs, which captures the energy of the sun. Vitamin B12, the most complex tetrapyrrole, is involved in DNA synthesis and energy metabolism [2]. The major product of tetrapyrrole biosynthesis in non-photosynthetic organisms is heme, an iron-coordinated porphyrin with the capacity to transfer electrons and bind diatomic gases. Here we summarize the current understanding of different aspects of heme metabolism in parasitic eukaryotes, including the synthesis and uptake of heme and its detoxification. A differential need for heme in distinct parasitic groups and the suitability of heme metabolism as a drug target for treating parasite-borne diseases are also discussed. First, however, let us review the functions of heme in various cellular processes. (en)
Title	Make It, Take It, or Leave It: Heme Metabolism of Parasites Make It, Take It, or Leave It: Heme Metabolism of Parasites (en)
skos:prefLabel	Make It, Take It, or Leave It: Heme Metabolism of Parasites Make It, Take It, or Leave It: Heme Metabolism of Parasites (en)
skos:notation	RIV/60077344:_____/13:00392770!RIV14-AV0-60077344
http://linked.open...avai/riv/aktivita	I P V
http://linked.open...avai/riv/aktivity	I, P(GAP305/11/2179), V
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Lukeš, Julius Oborník, Miroslav Kořený, Luděk
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	85795
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/13:00392770
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Apicomplexan parasites; biosynthesis pathway; evolution; protein (en)
http://linked.open.../riv/klicoveSlovo	Apicomplexan parasites biosynthesis pathway evolution protein
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[7C06BB72515D]
http://linked.open...i/riv/nazevZdroje	Plos Pathogens
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Characterization of Fe-S cluster assembly in Trypanosoma brucei
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	9
http://linked.open...iv/tvurceVysledku	Lukeš, Julius Oborník, Miroslav Kořený, Luděk
http://linked.open...ain/vavai/riv/wos	000314464600008
issn	1553-7374
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1371/journal.ppat.1003088

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