About: Dual core processing: MRB1 is an emerging kinetoplast RNA editing complex

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About: Dual core processing: MRB1 is an emerging kinetoplast RNA editing complex Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Our understanding of kinetoplastid RNA (kRNA) editing has centered on this paradigm: guide RNAs (gRNAs) provide a blueprint for uridine insertion/deletion into mitochondrial mRNAs by the RNA editing core complex (RECC). The characterization of constituent subunits of the mitochondrial RNA-binding complex 1 (MRB1) implies that it too is vital to the editing process. The recently elucidated MRB1 architecture will be instrumental in putting functional data from individual subunits into context. Our model depicts two functions for MRB1: mediating multi-round kRNA editing by coordinating the exchange of multiple gRNAs required by RECC to edit lengthy regions of mRNAs, and then linking kRNA editing with other RNA processing events. Our understanding of kinetoplastid RNA (kRNA) editing has centered on this paradigm: guide RNAs (gRNAs) provide a blueprint for uridine insertion/deletion into mitochondrial mRNAs by the RNA editing core complex (RECC). The characterization of constituent subunits of the mitochondrial RNA-binding complex 1 (MRB1) implies that it too is vital to the editing process. The recently elucidated MRB1 architecture will be instrumental in putting functional data from individual subunits into context. Our model depicts two functions for MRB1: mediating multi-round kRNA editing by coordinating the exchange of multiple gRNAs required by RECC to edit lengthy regions of mRNAs, and then linking kRNA editing with other RNA processing events. (en)
Title	Dual core processing: MRB1 is an emerging kinetoplast RNA editing complex Dual core processing: MRB1 is an emerging kinetoplast RNA editing complex (en)
skos:prefLabel	Dual core processing: MRB1 is an emerging kinetoplast RNA editing complex Dual core processing: MRB1 is an emerging kinetoplast RNA editing complex (en)
skos:notation	RIV/60077344:_____/13:00392769!RIV14-AV0-60077344
http://linked.open...avai/riv/aktivita	I P V
http://linked.open...avai/riv/aktivity	I, P(GA204/09/1667), P(GAP305/12/2261), V
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Lukeš, Julius Hashimi, Hassan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	70664
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/13:00392769
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	kinetoplastida; trypanosome; RNA editing; protein complexes; RECC; MRB1 (en)
http://linked.open.../riv/klicoveSlovo	RNA editing protein complexes trypanosome MRB1 RECC kinetoplastida
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[80DFAA8CAE36]
http://linked.open...i/riv/nazevZdroje	Trends in Parasitology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Characterization of the mitoproteome of the parasitic protist Trypanosoma brucei by means of recombinogenic engineering Characterization of a novel protein complex involved in RNA processing and editing in the mitochondrion of Trypanosoma brucei
http://linked.open...UplatneniVysledku	2013
http://linked.open...v/svazekPeriodika	29
http://linked.open...iv/tvurceVysledku	Lukeš, Julius Hashimi, Hassan Ammerman, M. L. Read, L. K. Zimmer, S. L.
http://linked.open...ain/vavai/riv/wos	000315180200006
issn	1471-4922
number of pages	9 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.pt.2012.11.005

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