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  • Anaplasma phagocytophilum is an obligate intracellular rickettsial pathogen transmitted by ixodid ticks. This bacterium colonizes myeloid and nonmyeloid cells and causes human granulocytic anaplasmosis - an important immunopathological vector-borne disease in the USA, Europe and Asia. Recent studies uncovered novel insights into the mechanisms of A. phagocytophilum pathogenesis and immunity. Here, we provide an overview of the underlying events by which the immune system responds to A. phagocytophilum infection, how this pathogen counteracts host immunity and the contribution of the tick vector for microbial transmission. We also discuss current scientific gaps in the knowledge of A. phagocytophilum biology for the purpose of exchanging research perspectives.
  • Anaplasma phagocytophilum is an obligate intracellular rickettsial pathogen transmitted by ixodid ticks. This bacterium colonizes myeloid and nonmyeloid cells and causes human granulocytic anaplasmosis - an important immunopathological vector-borne disease in the USA, Europe and Asia. Recent studies uncovered novel insights into the mechanisms of A. phagocytophilum pathogenesis and immunity. Here, we provide an overview of the underlying events by which the immune system responds to A. phagocytophilum infection, how this pathogen counteracts host immunity and the contribution of the tick vector for microbial transmission. We also discuss current scientific gaps in the knowledge of A. phagocytophilum biology for the purpose of exchanging research perspectives. (en)
Title
  • Anaplasma phagocytophilum: deceptively simple or simply deceptive?
  • Anaplasma phagocytophilum: deceptively simple or simply deceptive? (en)
skos:prefLabel
  • Anaplasma phagocytophilum: deceptively simple or simply deceptive?
  • Anaplasma phagocytophilum: deceptively simple or simply deceptive? (en)
skos:notation
  • RIV/60077344:_____/12:00377654!RIV13-AV0-60077344
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • I
http://linked.open...iv/cisloPeriodika
  • 6
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
  • Kotsyfakis, Michalis
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 122720
http://linked.open...ai/riv/idVysledku
  • RIV/60077344:_____/12:00377654
http://linked.open...riv/jazykVysledku
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  • obligate intracellular bacterium; rickettsial agents; ticks; vector-borne diseases (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [FA321F10B156]
http://linked.open...i/riv/nazevZdroje
  • Future Microbiology
http://linked.open...in/vavai/riv/obor
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http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 7
http://linked.open...iv/tvurceVysledku
  • Kotsyfakis, Michalis
  • Pedra, J. H. F.
  • Severo, M. S.
  • Stephens, K. D.
http://linked.open...ain/vavai/riv/wos
  • 000305658600009
issn
  • 1746-0913
number of pages
http://bibframe.org/vocab/doi
  • 10.2217/FMB.12.45
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