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  • Type I interferons (IFN-a and IFN-beta) are crucial determinants of the host immune response and tick saliva modulates this response, thus facilitating the transmission of tickborne pathogens. The current study therefore examines the effect of Ixodes ricinus tick saliva on IFN-beta signalling in murine dendritic cells using lipopolysaccharide (LPS) and Borrelia afzelii spirochaetes as inducers. Our results show that Borrelia-induced activation of STAT-1 was suppressed by tick saliva. Our data indicate that similar to I. ricinus tick saliva may modulate the host immune response by attenuating the initial signal transduction pathway of type I IFN.
  • Type I interferons (IFN-a and IFN-beta) are crucial determinants of the host immune response and tick saliva modulates this response, thus facilitating the transmission of tickborne pathogens. The current study therefore examines the effect of Ixodes ricinus tick saliva on IFN-beta signalling in murine dendritic cells using lipopolysaccharide (LPS) and Borrelia afzelii spirochaetes as inducers. Our results show that Borrelia-induced activation of STAT-1 was suppressed by tick saliva. Our data indicate that similar to I. ricinus tick saliva may modulate the host immune response by attenuating the initial signal transduction pathway of type I IFN. (en)
Title
  • Tick saliva suppresses IFN signalling in dendritic cells upon Borrelia afzelii infection
  • Tick saliva suppresses IFN signalling in dendritic cells upon Borrelia afzelii infection (en)
skos:prefLabel
  • Tick saliva suppresses IFN signalling in dendritic cells upon Borrelia afzelii infection
  • Tick saliva suppresses IFN signalling in dendritic cells upon Borrelia afzelii infection (en)
skos:notation
  • RIV/60077344:_____/12:00375992!RIV13-AV0-60077344
http://linked.open...avai/riv/aktivita
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  • I, P(LC06009)
http://linked.open...iv/cisloPeriodika
  • 1
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  • 174427
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  • RIV/60077344:_____/12:00375992
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  • Borrelia; dendritic cells; interferon signalling; tick saliva (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV
  • [37D82870C073]
http://linked.open...i/riv/nazevZdroje
  • Parasite immunology
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  • 34
http://linked.open...iv/tvurceVysledku
  • Kopecký, Jan
  • Lieskovská, Jaroslava
http://linked.open...ain/vavai/riv/wos
  • 000298594000005
issn
  • 0141-9838
number of pages
http://bibframe.org/vocab/doi
  • 10.1111/j.1365-3024.2011.01345.x
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