About: Defibrotide Interferes With Several Steps of the Coagulation-Inflammation Cycle and Exhibits Therapeutic Potential to Treat Severe Malaria

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The therapeutic use of defibrotide (DF) in malaria is proposed. DF blocks the induction of endothelial tissue factor-mediated coagulation by parasitized red blood cells. At a concentration achievable in vivo, DF suppresses Toll-like receptors 4 and 2 agonist-driven proinflammatory cytokine production by dendritic cells (DCs). We demonstrate that DF directly decreases platelet aggregation and blocks the alternative complement pathway further proposing that DF may act through adenosine receptors. Accordingly, we observe that DF-exposed DCs produce prostaglandin E2 and have enhanced lipopolysaccharide-induced IL-10 secretion. DF blocks parasite invasion of red blood cells and rosetting and the agglutination of parasitized red blood cells. Finally, DF abolishes oocysts development in Anopheles gambiae; in a murine model of cerebral malaria, DF affected parasitemia, decreased IFN-γ levels, and ameliorated clinical score (day 5) with a trend for increased survival. The therapeutic use of defibrotide (DF) in malaria is proposed. DF blocks the induction of endothelial tissue factor-mediated coagulation by parasitized red blood cells. At a concentration achievable in vivo, DF suppresses Toll-like receptors 4 and 2 agonist-driven proinflammatory cytokine production by dendritic cells (DCs). We demonstrate that DF directly decreases platelet aggregation and blocks the alternative complement pathway further proposing that DF may act through adenosine receptors. Accordingly, we observe that DF-exposed DCs produce prostaglandin E2 and have enhanced lipopolysaccharide-induced IL-10 secretion. DF blocks parasite invasion of red blood cells and rosetting and the agglutination of parasitized red blood cells. Finally, DF abolishes oocysts development in Anopheles gambiae; in a murine model of cerebral malaria, DF affected parasitemia, decreased IFN-γ levels, and ameliorated clinical score (day 5) with a trend for increased survival. (en)
Title	Defibrotide Interferes With Several Steps of the Coagulation-Inflammation Cycle and Exhibits Therapeutic Potential to Treat Severe Malaria Defibrotide Interferes With Several Steps of the Coagulation-Inflammation Cycle and Exhibits Therapeutic Potential to Treat Severe Malaria (en)
skos:prefLabel	Defibrotide Interferes With Several Steps of the Coagulation-Inflammation Cycle and Exhibits Therapeutic Potential to Treat Severe Malaria Defibrotide Interferes With Several Steps of the Coagulation-Inflammation Cycle and Exhibits Therapeutic Potential to Treat Severe Malaria (en)
skos:notation	RIV/60077344:_____/12:00375991!RIV13-AV0-60077344
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z60220518)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Kotsyfakis, Michalis
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	129844
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/12:00375991
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	anticoagulants; blood coagulation; endothelium; microcirculation; vascular biology; malaria; defibrotide; inflammation (en)
http://linked.open.../riv/klicoveSlovo	anticoagulants microcirculation endothelium blood coagulation malaria inflammation defibrotide vascular biology
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[681A29E0EDD3]
http://linked.open...i/riv/nazevZdroje	Arteriosclerosis Thrombosis and Vascular Biology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	25 (xsd:int)
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	32
http://linked.open...iv/tvurceVysledku	Francischetti, I.M.B. Kotsyfakis, Michalis Monteiro, R.Q. Oliveira, C. J. Ribeiro, J.M.C. Sa-Nunes, A. Wang, X. Ackerman, H. C. Carregaro, V. Debierre-Grockiego, F. Gomes, R. B. Hume, J. C. C. Iacobelli, M. Jaramillo-Gutierrez, G. Jiang, L. Lin, Ch. K. Long, C. A. Moretz, S. E. Ostera, G. R. Schwarz, R. T. Seydel, K. B. Srinivasan, P. Vickers, B. K. Waisberg, M. Yager, S. B.
http://linked.open...ain/vavai/riv/wos	000300639300035
http://linked.open...n/vavai/riv/zamer	Parazitismus a parazito-hostitelské vztahy na organismální, buněčné a molekulové úrovni
issn	1079-5642
number of pages	12 (xsd:int)
http://bibframe.org/vocab/doi	10.1161/ATVBAHA.111.240291

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