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rdf:type
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Description
| - We identified a novel clock-controlled gene (quasimodo), which encodes a light-responsive and membrane-anchored Zona Pellucida domain protein that supports light-dependent TIM degradation. Whereas wild type flies become arrhythmic in constant light (LL), quasimodo mutants elicit rhythmic expression of clock proteins and behavior in LL. QUASIMODO can function independently of CRY and is predominantly expressed within the CRY-negative DN3 clock neurons. Interestingly, downregulation of qsm in the clock circuit restores LL PERIOD protein rhythms in the qsm-negative DN1, indicating that qsm-mediated light-input is not cell-autonomous and can be accessed by the clock circuit. Our findings indicate that QUASIMODO constitutes part of a novel light-input to the circadian clock. Its light-responsive character in conjunction with the predicted localization at the outer neuronal membrane, suggests that QUASIMODO function is linked to electrical properties of clock neurons.
- We identified a novel clock-controlled gene (quasimodo), which encodes a light-responsive and membrane-anchored Zona Pellucida domain protein that supports light-dependent TIM degradation. Whereas wild type flies become arrhythmic in constant light (LL), quasimodo mutants elicit rhythmic expression of clock proteins and behavior in LL. QUASIMODO can function independently of CRY and is predominantly expressed within the CRY-negative DN3 clock neurons. Interestingly, downregulation of qsm in the clock circuit restores LL PERIOD protein rhythms in the qsm-negative DN1, indicating that qsm-mediated light-input is not cell-autonomous and can be accessed by the clock circuit. Our findings indicate that QUASIMODO constitutes part of a novel light-input to the circadian clock. Its light-responsive character in conjunction with the predicted localization at the outer neuronal membrane, suggests that QUASIMODO function is linked to electrical properties of clock neurons. (en)
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Title
| - QUASIMODO, a novel GPI-anchored zona pellucida protein involved in light input to the Drosophila circadian clock
- QUASIMODO, a novel GPI-anchored zona pellucida protein involved in light input to the Drosophila circadian clock (en)
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skos:prefLabel
| - QUASIMODO, a novel GPI-anchored zona pellucida protein involved in light input to the Drosophila circadian clock
- QUASIMODO, a novel GPI-anchored zona pellucida protein involved in light input to the Drosophila circadian clock (en)
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skos:notation
| - RIV/60077344:_____/11:00367836!RIV12-MSM-60077344
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(LC07032), Z(AV0Z50070508), Z(MSM6007665801)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/60077344:_____/11:00367836
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - QUASIMODO; Drosophila; circadian clock (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Sehadová, Hana
- Chen, K. F.
- Peschel, N.
- Stanewsky, R.
- Závodská, Radka
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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http://bibframe.org/vocab/doi
| - 10.1016/j.cub.2011.03.049
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