About: Trypanosoma brucei Mitochondrial Respiratome: Composition and Organization in Procyclic Form

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The mitochondrial respiratory chain is comprised of four different protein complexes (I-IV), which are responsible for electron transport and generation of proton gradient in the mitochondrial intermembrane space. In this study, the respiratory complexes I, II, and III were affinity purified from Trypanosoma brucei procyclic form cells and their composition was determined by mass spectrometry. The results showed that the respiratome of Trypanosoma is divergent because many of its proteins are unique to this group of organisms. Proteomics data from analyses of complexes purified using numerous tagged component proteins in each of the five complexes were used to generate the first predicted protein-protein interaction network of the Trypanosoma brucei respiratory chain. These results provide the first comprehensive insight into the unique composition of the respiratory complexes in Trypanosoma brucei, an early diverged eukaryotic pathogen. The mitochondrial respiratory chain is comprised of four different protein complexes (I-IV), which are responsible for electron transport and generation of proton gradient in the mitochondrial intermembrane space. In this study, the respiratory complexes I, II, and III were affinity purified from Trypanosoma brucei procyclic form cells and their composition was determined by mass spectrometry. The results showed that the respiratome of Trypanosoma is divergent because many of its proteins are unique to this group of organisms. Proteomics data from analyses of complexes purified using numerous tagged component proteins in each of the five complexes were used to generate the first predicted protein-protein interaction network of the Trypanosoma brucei respiratory chain. These results provide the first comprehensive insight into the unique composition of the respiratory complexes in Trypanosoma brucei, an early diverged eukaryotic pathogen. (en)
Title	Trypanosoma brucei Mitochondrial Respiratome: Composition and Organization in Procyclic Form Trypanosoma brucei Mitochondrial Respiratome: Composition and Organization in Procyclic Form (en)
skos:prefLabel	Trypanosoma brucei Mitochondrial Respiratome: Composition and Organization in Procyclic Form Trypanosoma brucei Mitochondrial Respiratome: Composition and Organization in Procyclic Form (en)
skos:notation	RIV/60077344:_____/11:00367704!RIV12-AV0-60077344
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GP204/09/P563), Z(AV0Z60220518)
http://linked.open...iv/cisloPeriodika	9
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Zíková, Alena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	236155
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/11:00367704
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	SUCCINATE DEHYDROGENASE; EDITED MESSENGER-RNA; COMPLEX-I; TRYPANOSOMA-BRUCEI; UBIQUINONE OXIDOREDUCTASE; TAP-TAG; PROTEIN INTERACTION; ALTERNATIVE OXIDASE; STATISTICAL-MODEL; MASS-SPECTROMETRY (en)
http://linked.open.../riv/klicoveSlovo	MASS-SPECTROMETRY TRYPANOSOMA-BRUCEI ALTERNATIVE OXIDASE COMPLEX-I EDITED MESSENGER-RNA PROTEIN INTERACTION STATISTICAL-MODEL SUCCINATE DEHYDROGENASE TAP-TAG UBIQUINONE OXIDOREDUCTASE
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[71F5E61CF317]
http://linked.open...i/riv/nazevZdroje	Molecular and Cellular Proteomics
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Functional analysis of two novel subunits of the F0F1-ATP synthase complex in Trypanosoma brucei
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	10
http://linked.open...iv/tvurceVysledku	Acestor, N. Anupama, A. Dalley, R. A. Panigrahi, A. K. Stuart, K. D. Zíková, Alena
http://linked.open...ain/vavai/riv/wos	000294729200007
http://linked.open...n/vavai/riv/zamer	Parazitismus a parazito-hostitelské vztahy na organismální, buněčné a molekulové úrovni
issn	1535-9476
number of pages	14 (xsd:int)
http://bibframe.org/vocab/doi	10.1074/mcp.M110.006908

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