About: Relation of genetic phylogeny and geographical distance of tick-borne encephalitis virus in central Europe

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Tick-borne encephalitis virus (TBEV) is the most important arboviral agent causing disease of the central nervous system in central Europe. In this study, 61 TBEV E gene sequences derived from 48 isolates from the Czech Republic (CR), and 4 isolates and 9 TBEV strains detected in ticks from Germany (1954 to 2009), were sequenced and subjected to phylogenetic and Bayesian phylodynamic. The general Eurasian continental east-to-west pattern of the spread of TBEV was confirmed at the regional level but is interlaced with spreading that arises because of local geography and anthropogenic influence. This spread is reflected by the disease pattern in the CR that has been observed since 1991. The overall evolutionary rate was estimated to be approximately 8x10(-4) substitutions per nucleotide per year. The analysis of the TBEV E genes of 11 strains isolated at one natural focus in Zd'ar Kaplice proved for the first time that TBEV is indeed subject to local evolution. Tick-borne encephalitis virus (TBEV) is the most important arboviral agent causing disease of the central nervous system in central Europe. In this study, 61 TBEV E gene sequences derived from 48 isolates from the Czech Republic (CR), and 4 isolates and 9 TBEV strains detected in ticks from Germany (1954 to 2009), were sequenced and subjected to phylogenetic and Bayesian phylodynamic. The general Eurasian continental east-to-west pattern of the spread of TBEV was confirmed at the regional level but is interlaced with spreading that arises because of local geography and anthropogenic influence. This spread is reflected by the disease pattern in the CR that has been observed since 1991. The overall evolutionary rate was estimated to be approximately 8x10(-4) substitutions per nucleotide per year. The analysis of the TBEV E genes of 11 strains isolated at one natural focus in Zd'ar Kaplice proved for the first time that TBEV is indeed subject to local evolution. (en)
Title	Relation of genetic phylogeny and geographical distance of tick-borne encephalitis virus in central Europe Relation of genetic phylogeny and geographical distance of tick-borne encephalitis virus in central Europe (en)
skos:prefLabel	Relation of genetic phylogeny and geographical distance of tick-borne encephalitis virus in central Europe Relation of genetic phylogeny and geographical distance of tick-borne encephalitis virus in central Europe (en)
skos:notation	RIV/60077344:_____/11:00364901!RIV12-MSM-60077344
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GAP502/11/2116), P(GPP302/10/P438), P(LC06009), Z(AV0Z60220518)
http://linked.open...iv/cisloPeriodika	Part 8
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Růžek, Daniel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	226381
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/11:00364901
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	IXODES-RICINUS; NATURAL FOCI; ROE DEER; ENDEMIC AREA; RUSSIA; FLAVIVIRUSES; EVOLUTION; VECTOR; SWEDEN; JAPAN (en)
http://linked.open.../riv/klicoveSlovo	EVOLUTION VECTOR ENDEMIC AREA FLAVIVIRUSES IXODES-RICINUS JAPAN NATURAL FOCI ROE DEER RUSSIA SWEDEN
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[62A6CCB410B9]
http://linked.open...i/riv/nazevZdroje	Journal of General Virology
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...vavai/riv/projekt	Centre for molecular ecology of vectors and pathogens Differences in clinical course of tick-borne encephalitis in host, and their genetic determination Role of the blood-brain barrier in tick-borne encephalitis neuropathogenesis
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	92
http://linked.open...iv/tvurceVysledku	Růžek, Daniel Pfeffer, M. Dobler, G. Essbauer, S. Hufert, F.T. Křivanec, K. Weidmann, M. Zanotto, P. M. de A. Zoeller, G.
http://linked.open...ain/vavai/riv/wos	000293488800020
http://linked.open...n/vavai/riv/zamer	Parazitismus a parazito-hostitelské vztahy na organismální, buněčné a molekulové úrovni
issn	0022-1317
number of pages	11 (xsd:int)
http://bibframe.org/vocab/doi	10.1099/vir.0.032417-0

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