About: Alboserpin, a Factor Xa Inhibitor from the Mosquito Vector of Yellow Fever, Binds Heparin and Membrane Phospholipids and Exhibits Antithrombotic Activity

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About: Alboserpin, a Factor Xa Inhibitor from the Mosquito Vector of Yellow Fever, Binds Heparin and Membrane Phospholipids and Exhibits Antithrombotic Activity Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The function of a mosquito anticoagulant serpin named as Alboserpin is presented. The recombinant protein binds to phospholipids and it inhibits the activity of human coagulation factor Xa. Binding is highly specific and is not detectable for FX, catalytic site-blocked FXa, thrombin and 12 other enzymes. Alboserpin displays high-affinity binding to heparin, but no change in FXa inhibition was observed in the presence of the cofactor, implying that bridging mechanisms did not take place. Alboserpin displays a potent pharmacological activity since it prevents thrombus formation provoked by ferric chloride injury of the carotid artery and it increases bleeding in a dose-dependent manner. The function of a mosquito anticoagulant serpin named as Alboserpin is presented. The recombinant protein binds to phospholipids and it inhibits the activity of human coagulation factor Xa. Binding is highly specific and is not detectable for FX, catalytic site-blocked FXa, thrombin and 12 other enzymes. Alboserpin displays high-affinity binding to heparin, but no change in FXa inhibition was observed in the presence of the cofactor, implying that bridging mechanisms did not take place. Alboserpin displays a potent pharmacological activity since it prevents thrombus formation provoked by ferric chloride injury of the carotid artery and it increases bleeding in a dose-dependent manner. (en)
Title	Alboserpin, a Factor Xa Inhibitor from the Mosquito Vector of Yellow Fever, Binds Heparin and Membrane Phospholipids and Exhibits Antithrombotic Activity Alboserpin, a Factor Xa Inhibitor from the Mosquito Vector of Yellow Fever, Binds Heparin and Membrane Phospholipids and Exhibits Antithrombotic Activity (en)
skos:prefLabel	Alboserpin, a Factor Xa Inhibitor from the Mosquito Vector of Yellow Fever, Binds Heparin and Membrane Phospholipids and Exhibits Antithrombotic Activity Alboserpin, a Factor Xa Inhibitor from the Mosquito Vector of Yellow Fever, Binds Heparin and Membrane Phospholipids and Exhibits Antithrombotic Activity (en)
skos:notation	RIV/60077344:_____/11:00364839!RIV12-AV0-60077344
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(AV0Z60220518)
http://linked.open...iv/cisloPeriodika	32
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Kotsyfakis, Michalis
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	185138
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/11:00364839
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	serpin; mosquito; Aedes albopictus; phospholipids; Factor Xa; heparin; binding affinity; coagulation; thrombus; bleeding (en)
http://linked.open.../riv/klicoveSlovo	bleeding coagulation Aedes albopictus Factor Xa binding affinity heparin mosquito phospholipids serpin thrombus
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[BFB27A5AA8C0]
http://linked.open...i/riv/nazevZdroje	Journal of Biological Chemistry
http://linked.open...in/vavai/riv/obor	GJ
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	9 (xsd:int)
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	286
http://linked.open...iv/tvurceVysledku	Andersen, J. F. Calvo, E. Francischetti, I.M.B. Kotsyfakis, Michalis Mans, B. J. Mizurini, D. M. Monteiro, R.Q. Ribeiro, J.M.C. Sa-Nunes, A.
http://linked.open...ain/vavai/riv/wos	000293557800018
http://linked.open...n/vavai/riv/zamer	Parazitismus a parazito-hostitelské vztahy na organismální, buněčné a molekulové úrovni
issn	0021-9258
number of pages	13 (xsd:int)
http://bibframe.org/vocab/doi	10.1074/jbc.M111.247924

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