About: Systematically fragmented genes in a multipartite mitochondrial genome

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The most bizarre mitochondrial DNA (mtDNA) is that of the euglenozoan eukaryote Diplonema papillatum. The genome consists of numerous small circular chromosomes none of which appears to encode a complete gene. We examined how many genes are encoded by Diplonema mtDNA and whether all are fragmented and their transcripts trans-spliced. By employing most sensitive protein profile search algorithms and comparing genomic with cDNA sequence, we recognize a total of 11 typical mitochondrial genes. The 10 protein-coding genes are systematically chopped up into three to 12 modules of 60-350 bp length. The corresponding mRNAs are all trans-spliced. Our results open new intriguing questions about the biochemistry and evolution of mitochondrial trans-splicing in Diplonema. The most bizarre mitochondrial DNA (mtDNA) is that of the euglenozoan eukaryote Diplonema papillatum. The genome consists of numerous small circular chromosomes none of which appears to encode a complete gene. We examined how many genes are encoded by Diplonema mtDNA and whether all are fragmented and their transcripts trans-spliced. By employing most sensitive protein profile search algorithms and comparing genomic with cDNA sequence, we recognize a total of 11 typical mitochondrial genes. The 10 protein-coding genes are systematically chopped up into three to 12 modules of 60-350 bp length. The corresponding mRNAs are all trans-spliced. Our results open new intriguing questions about the biochemistry and evolution of mitochondrial trans-splicing in Diplonema. (en)
Title	Systematically fragmented genes in a multipartite mitochondrial genome Systematically fragmented genes in a multipartite mitochondrial genome (en)
skos:prefLabel	Systematically fragmented genes in a multipartite mitochondrial genome Systematically fragmented genes in a multipartite mitochondrial genome (en)
skos:notation	RIV/60077344:_____/11:00356039!RIV13-GA0-60077344
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(1M0520), P(GA204/09/1667), Z(AV0Z50520514), Z(AV0Z60220518), Z(MSM6007665801)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Lukeš, Julius
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	234081
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/11:00356039
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	mtDNA genome; gene fragmentation; RNA editing (en)
http://linked.open.../riv/klicoveSlovo	RNA editing gene fragmentation mtDNA genome
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[C0A1CFF5D39E]
http://linked.open...i/riv/nazevZdroje	Nucleic Acids Research
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Center for Applied Genomics Characterization of a novel protein complex involved in RNA processing and editing in the mitochondrion of Trypanosoma brucei
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	39
http://linked.open...iv/tvurceVysledku	Lukeš, Julius Vlček, Čestmír Burger, G. Marande, W. Teijeiro, S.
http://linked.open...ain/vavai/riv/wos	000287257500024
http://linked.open...n/vavai/riv/zamer	Molekulárně genetické a buněčné základy klíčových biologických procesů: genová exprese, onkogeneze, replikace virů, imunita a vývoj organismů Parazitismus a parazito-hostitelské vztahy na organismální, buněčné a molekulové úrovni EKOLOGICKÉ, EVOLUČNÍ A EXPERIMENTÁLNĚ BIOLOGICKÉ PŘÍSTUPY KE STUDIU VZNIKU A VÝZNAMU BIODIVERZITY
issn	0305-1048
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1093/nar/gkq883

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