About: Nostotrebin 6, a bis(cyclopentenedione) with cholinesterase inhibitory activity isolated from Nostoc sp str. Lukesova 27/97

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About: Nostotrebin 6, a bis(cyclopentenedione) with cholinesterase inhibitory activity isolated from Nostoc sp str. Lukesova 27/97 Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Nostotrebin 6, a new polyphenolic compound with a fully substituted 2,2-bis(cyclopent-4-en-1,3-dione) skeleton, was isolated from a methanolic extract of the cyanobacterial strain Nostoc sp. str. Lukešová 27/97. The structure of this compound was determined using X-ray crystallography and further supported by NMR, IR spectroscopy, and MS. Nostotrebin 6 is an S-parabolic I-parabolic noncompetitive inhibitor of acetylcholinesterase (IC50 is 5.5 microM) and an S-parabolic I-parabolic mixed inhibitor of butyrylcholinesterase (IC50 is 6.1–7.5 microM). The inhibitory potency of nostotrebin 6 was compared with that of tacrine and galanthamine Nostotrebin 6, a new polyphenolic compound with a fully substituted 2,2-bis(cyclopent-4-en-1,3-dione) skeleton, was isolated from a methanolic extract of the cyanobacterial strain Nostoc sp. str. Lukešová 27/97. The structure of this compound was determined using X-ray crystallography and further supported by NMR, IR spectroscopy, and MS. Nostotrebin 6 is an S-parabolic I-parabolic noncompetitive inhibitor of acetylcholinesterase (IC50 is 5.5 microM) and an S-parabolic I-parabolic mixed inhibitor of butyrylcholinesterase (IC50 is 6.1–7.5 microM). The inhibitory potency of nostotrebin 6 was compared with that of tacrine and galanthamine (en)
Title	Nostotrebin 6, a bis(cyclopentenedione) with cholinesterase inhibitory activity isolated from Nostoc sp str. Lukesova 27/97 Nostotrebin 6, a bis(cyclopentenedione) with cholinesterase inhibitory activity isolated from Nostoc sp str. Lukesova 27/97 (en)
skos:prefLabel	Nostotrebin 6, a bis(cyclopentenedione) with cholinesterase inhibitory activity isolated from Nostoc sp str. Lukesova 27/97 Nostotrebin 6, a bis(cyclopentenedione) with cholinesterase inhibitory activity isolated from Nostoc sp str. Lukesova 27/97 (en)
skos:notation	RIV/60077344:_____/10:00351615!RIV11-MSM-60077344
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(ME 874), Z(AV0Z40550506), Z(AV0Z50200510), Z(AV0Z60660521), Z(MSM0021627502), Z(MSM6046137302)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Lukešová, Alena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	275145
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/10:00351615
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Cholinesterase inhibitor; cyclopentenedione; cyanobacteria (en)
http://linked.open.../riv/klicoveSlovo	Cholinesterase inhibitor cyanobacteria cyclopentenedione
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[2A77FA52A218]
http://linked.open...i/riv/nazevZdroje	Journal of Enzyme Inhibition and Medicinal Chemistry
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	7 (xsd:int)
http://linked.open...vavai/riv/projekt	http://linked.opendata.cz/resource/domain/vavai/projekt/ME%20874
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	25
http://linked.open...iv/tvurceVysledku	Buděšínský, Miloš Kopecký, Jiří Lukešová, Alena Čejka, J. Havlíček, Vladimír Zelík, Petr Čegan, A.
http://linked.open...ain/vavai/riv/wos	000276866900016
http://linked.open...n/vavai/riv/zamer	Regulace biologických procesů: Chemické modulátory vybraných systémů významných pro medicínu a zemědělství Microorganisms in Research and Biotechnology Relationships between the structure and function of decomposer food web in soil Pokročilé analytické a separační metody a jejich aplikace v diagnostice a technologii živých a neživých materiálů Preparation and research of functional materials and material technologies using micro- and nanoscopic methods
issn	1475-6366
number of pages	7 (xsd:int)

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