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  • While the single mitochondrion of trypanosomatid flagellates contains many of the hallmarks that are known from mitochondria in other conventional model organisms, it also possesses several unique features, making it a subject of intense research. Here, we summarize current knowledge of the (1) structure, maintenance and replication of the extensive kinetoplastid DNA network, (2) byzantine organellar RNA metabolism, including insertion/deletion RNA editing, (3) translation of mitochondrial-encoded proteins, and, finally, (4) distinctive aspects of energy metabolism of the organelle. While we focus on the mitochondrion of Trypanosoma brucei, particularly in the context of its radical physiological and biochemical changes during the life cycle of the parasite, in order to get a more complete picture of the workings of this fascinating organelle, we also discuss significant findings obtained from other trypanosomatids.
  • While the single mitochondrion of trypanosomatid flagellates contains many of the hallmarks that are known from mitochondria in other conventional model organisms, it also possesses several unique features, making it a subject of intense research. Here, we summarize current knowledge of the (1) structure, maintenance and replication of the extensive kinetoplastid DNA network, (2) byzantine organellar RNA metabolism, including insertion/deletion RNA editing, (3) translation of mitochondrial-encoded proteins, and, finally, (4) distinctive aspects of energy metabolism of the organelle. While we focus on the mitochondrion of Trypanosoma brucei, particularly in the context of its radical physiological and biochemical changes during the life cycle of the parasite, in order to get a more complete picture of the workings of this fascinating organelle, we also discuss significant findings obtained from other trypanosomatids. (en)
Title
  • The Remarkable Mitochondrion of Trypanosomes and Related Flagellates
  • The Remarkable Mitochondrion of Trypanosomes and Related Flagellates (en)
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  • The Remarkable Mitochondrion of Trypanosomes and Related Flagellates
  • The Remarkable Mitochondrion of Trypanosomes and Related Flagellates (en)
skos:notation
  • RIV/60077344:_____/10:00349085!RIV11-AV0-60077344
http://linked.open...avai/riv/aktivita
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  • Z(AV0Z60220518)
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  • 284737
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  • RIV/60077344:_____/10:00349085
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  • Mitochondrion; flagellates (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...ontrolniKodProRIV
  • [2CC012B7B4BE]
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  • Heidelberg
http://linked.open...vEdiceCisloSvazku
  • Microbiology Monographs, 17
http://linked.open...i/riv/nazevZdroje
  • Structures and Organelles in Pathogenic Protists Structures and Organelles in Pathogenic Protists
http://linked.open...in/vavai/riv/obor
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  • Lukeš, Julius
  • Verner, Zdeněk
  • Hashimi, Hassan
  • Číčová, Zdeňka
http://linked.open...n/vavai/riv/zamer
number of pages
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  • Springer-Verlag. Berlin
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  • 978-3-642-12862-2
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