About: YCF45 protein, usually associated with plastids, is targeted into the mitochondrion of Trypanosoma brucei

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About: YCF45 protein, usually associated with plastids, is targeted into the mitochondrion of Trypanosoma brucei Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	YCF45 belongs to a family of proteins of unknown function usually located in the chloroplast of plants. Its highly conserved homologues were found in the genomes of several Trypanosoma and Leishmania species. HA(3)-tagging of the YCF45 protein with the start codon as annotated in the Gene(DB) revealed its cytosolic localization in the cultured procyclic stage of Trypanosoma brucei. However, when a more upstream located start codon was used in another HA(3)-tagged construct, the resulting protein was targeted to the mitochondrion. We propose that YCF45 was acquired by an ancestral trypanosomatid by horizontal gene transfer and in the absence of a plastid was re-targeted to the mitochondrion. YCF45 belongs to a family of proteins of unknown function usually located in the chloroplast of plants. Its highly conserved homologues were found in the genomes of several Trypanosoma and Leishmania species. HA(3)-tagging of the YCF45 protein with the start codon as annotated in the Gene(DB) revealed its cytosolic localization in the cultured procyclic stage of Trypanosoma brucei. However, when a more upstream located start codon was used in another HA(3)-tagged construct, the resulting protein was targeted to the mitochondrion. We propose that YCF45 was acquired by an ancestral trypanosomatid by horizontal gene transfer and in the absence of a plastid was re-targeted to the mitochondrion. (en)
Title	YCF45 protein, usually associated with plastids, is targeted into the mitochondrion of Trypanosoma brucei YCF45 protein, usually associated with plastids, is targeted into the mitochondrion of Trypanosoma brucei (en)
skos:prefLabel	YCF45 protein, usually associated with plastids, is targeted into the mitochondrion of Trypanosoma brucei YCF45 protein, usually associated with plastids, is targeted into the mitochondrion of Trypanosoma brucei (en)
skos:notation	RIV/60077344:_____/10:00347288!RIV11-GA0-60077344
http://linked.open...avai/riv/aktivita	I P S Z
http://linked.open...avai/riv/aktivity	I, P(GA204/09/1667), P(LC07032), S, Z(AV0Z60220518), Z(MSM6007665801)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Týč, Jiří Jirků, Milan Lukeš, Julius Long, Shaojun
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	299103
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/10:00347288
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Trypanosoma; Plastid; Mitochondrion; Targeting; YCF45; Horizontal gene transfer (en)
http://linked.open.../riv/klicoveSlovo	Mitochondrion Trypanosoma Targeting Horizontal gene transfer Plastid YCF45
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[D0225678F083]
http://linked.open...i/riv/nazevZdroje	Molecular and Biochemical Parasitology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Characterization of a novel protein complex involved in RNA processing and editing in the mitochondrion of Trypanosoma brucei Center for Functional Genetics
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	173
http://linked.open...iv/tvurceVysledku	Jirků, Milan Lukeš, Julius Long, Shaojun Týč, Jiří
http://linked.open...ain/vavai/riv/wos	000279706900007
http://linked.open...n/vavai/riv/zamer	Parazitismus a parazito-hostitelské vztahy na organismální, buněčné a molekulové úrovni EKOLOGICKÉ, EVOLUČNÍ A EXPERIMENTÁLNĚ BIOLOGICKÉ PŘÍSTUPY KE STUDIU VZNIKU A VÝZNAMU BIODIVERZITY
issn	0166-6851
number of pages	5 (xsd:int)

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