About: Functions and cellular localization of cysteine desulfurase and selenocysteine lyase in Trypanosoma brucei

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About: Functions and cellular localization of cysteine desulfurase and selenocysteine lyase in Trypanosoma brucei Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	It was shown previously that the Nfs-like protein called Nfs from the parasitic protist Trypanosoma brucei is a genuine CysD. A second Nfs-like protein is encoded in the nuclear genome of T. brucei. We called this protein selenocysteine lyase (SCL) because phylogenetic analysis reveals that it is monophyletic with known eukaryotic selenocysteine lyases. The Nfs protein is located in the mitochondrion, whereas the SCL protein seems to be present in the nucleus and cytoplasm. Unexpectedly, downregulation of either Nfs or SCL protein leads to a dramatic decrease in both CysD and selenocysteine lyase activities concurrently in the mitochondrion and the cytosolic fractions. Because loss of Nfs causes a growth phenotype but loss of SCL does not, we propose that Nfs can fully complement SCL, whereas SCL can only partially replace Nfs under our growth conditions. It was shown previously that the Nfs-like protein called Nfs from the parasitic protist Trypanosoma brucei is a genuine CysD. A second Nfs-like protein is encoded in the nuclear genome of T. brucei. We called this protein selenocysteine lyase (SCL) because phylogenetic analysis reveals that it is monophyletic with known eukaryotic selenocysteine lyases. The Nfs protein is located in the mitochondrion, whereas the SCL protein seems to be present in the nucleus and cytoplasm. Unexpectedly, downregulation of either Nfs or SCL protein leads to a dramatic decrease in both CysD and selenocysteine lyase activities concurrently in the mitochondrion and the cytosolic fractions. Because loss of Nfs causes a growth phenotype but loss of SCL does not, we propose that Nfs can fully complement SCL, whereas SCL can only partially replace Nfs under our growth conditions. (en)
Title	Functions and cellular localization of cysteine desulfurase and selenocysteine lyase in Trypanosoma brucei Functions and cellular localization of cysteine desulfurase and selenocysteine lyase in Trypanosoma brucei (en)
skos:prefLabel	Functions and cellular localization of cysteine desulfurase and selenocysteine lyase in Trypanosoma brucei Functions and cellular localization of cysteine desulfurase and selenocysteine lyase in Trypanosoma brucei (en)
skos:notation	RIV/60077344:_____/10:00342953!RIV11-GA0-60077344
http://linked.open...avai/riv/aktivita	I P S Z
http://linked.open...avai/riv/aktivity	I, P(GA204/09/1667), P(LC06009), P(LC07032), S, Z(AV0Z60220518), Z(MSM6007665801)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Poliak, Pavel Lukeš, Julius Oborník, Miroslav Zíková, Alena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	259950
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/10:00342953
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Fe–S cluster; mitochondrion; RNAi; selenoprotein; Trypanosoma (en)
http://linked.open.../riv/klicoveSlovo	RNAi mitochondrion Trypanosoma selenoprotein Fe–S cluster
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[CA2A6E7435E9]
http://linked.open...i/riv/nazevZdroje	FEBS Journal
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Centre for molecular ecology of vectors and pathogens Characterization of a novel protein complex involved in RNA processing and editing in the mitochondrion of Trypanosoma brucei Center for Functional Genetics
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	277
http://linked.open...iv/tvurceVysledku	Lukeš, Julius Oborník, Miroslav Stuart, K. D. Zíková, Alena Poliak, Pavel Tachezy, J. Pilon, M. Van Hoewyk, D.
http://linked.open...ain/vavai/riv/wos	000273396000013
http://linked.open...n/vavai/riv/zamer	Parazitismus a parazito-hostitelské vztahy na organismální, buněčné a molekulové úrovni EKOLOGICKÉ, EVOLUČNÍ A EXPERIMENTÁLNĚ BIOLOGICKÉ PŘÍSTUPY KE STUDIU VZNIKU A VÝZNAMU BIODIVERZITY
issn	1742-464X
number of pages	11 (xsd:int)

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