About: Evolution of the haem synthetic pathway in kinetoplastid flagellates: An essential pathway that is not essential after all?     Goto   Sponge   NotDistinct   Permalink

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  • Kinetoplastid flagellates represent an interesting group of species, as some of them lost the complete pathway of haem synthesis while others possess only the last 3 biosynthetic steps. We decided to supplement a Current view on the phylogeny of these important pathogens with the expected state of haem synthesis in representative species. We propose a scenario in which the ancestor of all trypanosomatids was completely deficient of the synthesis of haem. In trypanosomatids other than members of the genus Trypanosoma, the pathway was partially rescued by genes encoding enzymes for the last three steps, Supposedly obtained by horizontal transfer from a gamma-proteobacterium. This event preceded the diversification of the non-Trypanosoma trypanosomatids. Later, some flagellates acquired a beta-proteobacterial endosymbiont which supplied them with haem precursors. The medically important trypanosomes have remained fully deficient of haem synthesis and obtain this compound from the host.
  • Kinetoplastid flagellates represent an interesting group of species, as some of them lost the complete pathway of haem synthesis while others possess only the last 3 biosynthetic steps. We decided to supplement a Current view on the phylogeny of these important pathogens with the expected state of haem synthesis in representative species. We propose a scenario in which the ancestor of all trypanosomatids was completely deficient of the synthesis of haem. In trypanosomatids other than members of the genus Trypanosoma, the pathway was partially rescued by genes encoding enzymes for the last three steps, Supposedly obtained by horizontal transfer from a gamma-proteobacterium. This event preceded the diversification of the non-Trypanosoma trypanosomatids. Later, some flagellates acquired a beta-proteobacterial endosymbiont which supplied them with haem precursors. The medically important trypanosomes have remained fully deficient of haem synthesis and obtain this compound from the host. (en)
Title
  • Evolution of the haem synthetic pathway in kinetoplastid flagellates: An essential pathway that is not essential after all?
  • Evolution of the haem synthetic pathway in kinetoplastid flagellates: An essential pathway that is not essential after all? (en)
skos:prefLabel
  • Evolution of the haem synthetic pathway in kinetoplastid flagellates: An essential pathway that is not essential after all?
  • Evolution of the haem synthetic pathway in kinetoplastid flagellates: An essential pathway that is not essential after all? (en)
skos:notation
  • RIV/60077344:_____/10:00342950!RIV11-GA0-60077344
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • P(GA206/08/1423), P(GD206/09/H026), P(LC07032), S, Z(AV0Z60220518), Z(MSM6007665801)
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 258028
http://linked.open...ai/riv/idVysledku
  • RIV/60077344:_____/10:00342950
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • haem synthesis; Kinetoplastida; evolution; horizontal gene transfer; bacterial endosymbiont (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • AU - Australské společenství
http://linked.open...ontrolniKodProRIV
  • [6D6A5B1240FB]
http://linked.open...i/riv/nazevZdroje
  • International Journal for Parasitology
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...vavai/riv/projekt
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 40
http://linked.open...iv/tvurceVysledku
  • Lukeš, Julius
  • Oborník, Miroslav
  • Kořený, Luděk
http://linked.open...ain/vavai/riv/wos
  • 000274447900002
http://linked.open...n/vavai/riv/zamer
issn
  • 0020-7519
number of pages
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