About: Evolution of the haem synthetic pathway in kinetoplastid flagellates: An essential pathway that is not essential after all?

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About: Evolution of the haem synthetic pathway in kinetoplastid flagellates: An essential pathway that is not essential after all? Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Kinetoplastid flagellates represent an interesting group of species, as some of them lost the complete pathway of haem synthesis while others possess only the last 3 biosynthetic steps. We decided to supplement a Current view on the phylogeny of these important pathogens with the expected state of haem synthesis in representative species. We propose a scenario in which the ancestor of all trypanosomatids was completely deficient of the synthesis of haem. In trypanosomatids other than members of the genus Trypanosoma, the pathway was partially rescued by genes encoding enzymes for the last three steps, Supposedly obtained by horizontal transfer from a gamma-proteobacterium. This event preceded the diversification of the non-Trypanosoma trypanosomatids. Later, some flagellates acquired a beta-proteobacterial endosymbiont which supplied them with haem precursors. The medically important trypanosomes have remained fully deficient of haem synthesis and obtain this compound from the host. Kinetoplastid flagellates represent an interesting group of species, as some of them lost the complete pathway of haem synthesis while others possess only the last 3 biosynthetic steps. We decided to supplement a Current view on the phylogeny of these important pathogens with the expected state of haem synthesis in representative species. We propose a scenario in which the ancestor of all trypanosomatids was completely deficient of the synthesis of haem. In trypanosomatids other than members of the genus Trypanosoma, the pathway was partially rescued by genes encoding enzymes for the last three steps, Supposedly obtained by horizontal transfer from a gamma-proteobacterium. This event preceded the diversification of the non-Trypanosoma trypanosomatids. Later, some flagellates acquired a beta-proteobacterial endosymbiont which supplied them with haem precursors. The medically important trypanosomes have remained fully deficient of haem synthesis and obtain this compound from the host. (en)
Title	Evolution of the haem synthetic pathway in kinetoplastid flagellates: An essential pathway that is not essential after all? Evolution of the haem synthetic pathway in kinetoplastid flagellates: An essential pathway that is not essential after all? (en)
skos:prefLabel	Evolution of the haem synthetic pathway in kinetoplastid flagellates: An essential pathway that is not essential after all? Evolution of the haem synthetic pathway in kinetoplastid flagellates: An essential pathway that is not essential after all? (en)
skos:notation	RIV/60077344:_____/10:00342950!RIV11-GA0-60077344
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(GA206/08/1423), P(GD206/09/H026), P(LC07032), S, Z(AV0Z60220518), Z(MSM6007665801)
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Lukeš, Julius Oborník, Miroslav Kořený, Luděk
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	258028
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/10:00342950
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	haem synthesis; Kinetoplastida; evolution; horizontal gene transfer; bacterial endosymbiont (en)
http://linked.open.../riv/klicoveSlovo	horizontal gene transfer evolution Kinetoplastida bacterial endosymbiont haem synthesis
http://linked.open...odStatuVydavatele	AU - Australské společenství
http://linked.open...ontrolniKodProRIV	[6D6A5B1240FB]
http://linked.open...i/riv/nazevZdroje	International Journal for Parasitology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Heme Biosynthesis in Euglenozoa Parasite-host relationships and the evolution of parasitism Center for Functional Genetics
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	40
http://linked.open...iv/tvurceVysledku	Lukeš, Julius Oborník, Miroslav Kořený, Luděk
http://linked.open...ain/vavai/riv/wos	000274447900002
http://linked.open...n/vavai/riv/zamer	Parazitismus a parazito-hostitelské vztahy na organismální, buněčné a molekulové úrovni EKOLOGICKÉ, EVOLUČNÍ A EXPERIMENTÁLNĚ BIOLOGICKÉ PŘÍSTUPY KE STUDIU VZNIKU A VÝZNAMU BIODIVERZITY
issn	0020-7519
number of pages	8 (xsd:int)

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