About: The assembly of F1FO-ATP synthase is disrupted upon interference of RNA editing in Trypanosoma brucei

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About: The assembly of F1FO-ATP synthase is disrupted upon interference of RNA editing in Trypanosoma brucei Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Taking advantage of the different phenotypes between RNA interference knock-down cell lines in which the expression of proteins involved in mtRNA metabolism and editing can be silenced, we provide support for the view that ATP6 is encoded in the mt genome of Trypanosoma species and that it is incorporated into complex V. The reduction of the F1FO oligomer of complex V coincides with the accumulation of the F, moiety in ATP6-lacking cells, which also appear to lack the F-O ATP9 multimeric ring. The oligomycin sensitivity of ATPase activity of complex V in ATP6-lacking cells is reduced, reflecting the insensitivity of the Dk and Ak cells to this drug. In addition, the F, moiety of complex V appears to exist as a dimer in steady state conditions and contains the ATP4 subunit traditionally assigned to the F-O sub-complex. Taking advantage of the different phenotypes between RNA interference knock-down cell lines in which the expression of proteins involved in mtRNA metabolism and editing can be silenced, we provide support for the view that ATP6 is encoded in the mt genome of Trypanosoma species and that it is incorporated into complex V. The reduction of the F1FO oligomer of complex V coincides with the accumulation of the F, moiety in ATP6-lacking cells, which also appear to lack the F-O ATP9 multimeric ring. The oligomycin sensitivity of ATPase activity of complex V in ATP6-lacking cells is reduced, reflecting the insensitivity of the Dk and Ak cells to this drug. In addition, the F, moiety of complex V appears to exist as a dimer in steady state conditions and contains the ATP4 subunit traditionally assigned to the F-O sub-complex. (en)
Title	The assembly of F1FO-ATP synthase is disrupted upon interference of RNA editing in Trypanosoma brucei The assembly of F1FO-ATP synthase is disrupted upon interference of RNA editing in Trypanosoma brucei (en)
skos:prefLabel	The assembly of F1FO-ATP synthase is disrupted upon interference of RNA editing in Trypanosoma brucei The assembly of F1FO-ATP synthase is disrupted upon interference of RNA editing in Trypanosoma brucei (en)
skos:notation	RIV/60077344:_____/10:00342884!RIV11-GA0-60077344
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA204/06/1558), P(IAA500960705), P(LC07032), Z(AV0Z60220518), Z(MSM6007665801)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Lukeš, Julius Hashimi, Hassan Lai, De Hua
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	247864
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/10:00342884
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	RNA editing; ATP synthase; mitochondrion; Trypanosoma; respiratory complex; membrane potential (en)
http://linked.open.../riv/klicoveSlovo	ATP synthase RNA editing mitochondrion respiratory complex Trypanosoma membrane potential
http://linked.open...odStatuVydavatele	AU - Australské společenství
http://linked.open...ontrolniKodProRIV	[D24558B02098]
http://linked.open...i/riv/nazevZdroje	International Journal for Parasitology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Center for Functional Genetics Functional analysis of mitochondrial proteins in Trypanosoma brucei The role of Trypanosoma brucei RNA binding proteins in mitochondrial transcript processing.
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	40
http://linked.open...iv/tvurceVysledku	Horváth, A. Lukeš, Julius Čermáková, P. Hashimi, Hassan Lai, De Hua Benkovičová, V.
http://linked.open...ain/vavai/riv/wos	000274104300005
http://linked.open...n/vavai/riv/zamer	Parazitismus a parazito-hostitelské vztahy na organismální, buněčné a molekulové úrovni EKOLOGICKÉ, EVOLUČNÍ A EXPERIMENTÁLNĚ BIOLOGICKÉ PŘÍSTUPY KE STUDIU VZNIKU A VÝZNAMU BIODIVERZITY
issn	0020-7519
number of pages	10 (xsd:int)

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