About: Characterization of ferritin 2 for the control of tick infestations

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Tick iron metabolism pathway was targeted in an effort to identify new tick protective antigens. Recombinant Ixodes ricinus (IrFER2) and Rhipicephalus microplus (RmFER2) ferritin 2 proteins were expressed in Escherichia coli and used to immunize rabbits and cattle, respectively. Vaccination with IrFER2 reduced I. ricinus tick numbers, weight and fertility in rabbits with an overall vaccine efficacy (E) of 98%. Control of cattle tick, R. microplus and Rhipicephalus annulatus infestations was obtained in vaccinated cattle with overall E of 64% and 72%, respectively. Notably, the efficacy of the RmFER2 vaccine was similar to that obtained with Bm86 against R. microplus. These collective results demonstrated the feasibility of using ferritin 2 to develop vaccines for the control of tick infestations. Tick iron metabolism pathway was targeted in an effort to identify new tick protective antigens. Recombinant Ixodes ricinus (IrFER2) and Rhipicephalus microplus (RmFER2) ferritin 2 proteins were expressed in Escherichia coli and used to immunize rabbits and cattle, respectively. Vaccination with IrFER2 reduced I. ricinus tick numbers, weight and fertility in rabbits with an overall vaccine efficacy (E) of 98%. Control of cattle tick, R. microplus and Rhipicephalus annulatus infestations was obtained in vaccinated cattle with overall E of 64% and 72%, respectively. Notably, the efficacy of the RmFER2 vaccine was similar to that obtained with Bm86 against R. microplus. These collective results demonstrated the feasibility of using ferritin 2 to develop vaccines for the control of tick infestations. (en)
Title	Characterization of ferritin 2 for the control of tick infestations Characterization of ferritin 2 for the control of tick infestations (en)
skos:prefLabel	Characterization of ferritin 2 for the control of tick infestations Characterization of ferritin 2 for the control of tick infestations (en)
skos:notation	RIV/60077344:_____/10:00342866!RIV12-MSM-60077344
http://linked.open...avai/riv/aktivita	P V Z
http://linked.open...avai/riv/aktivity	P(IAA600960910), P(LC06009), V, Z(AV0Z60220518), Z(MSM6007665801)
http://linked.open...iv/cisloPeriodika	17
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Kopáček, Petr Loosová, Gabriela Hajdušek, Ondřej
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	250422
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/10:00342866
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	tick ferritin 2; tick-protective vaccine (en)
http://linked.open.../riv/klicoveSlovo	tick ferritin 2 tick-protective vaccine
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[A8F72BC52C07]
http://linked.open...i/riv/nazevZdroje	Vaccine
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Centre for molecular ecology of vectors and pathogens The digestive system of ticks - the target for rational development of vaccine against ticks and tick-borne pathogens
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	28
http://linked.open...iv/tvurceVysledku	Kopáček, Petr Hajdušek, Ondřej Loosová, Gabriela Grubhoffer, L. Almazán, C. de la Fuente, J. Canales, M. Villar, M.
http://linked.open...ain/vavai/riv/wos	000276877900011
http://linked.open...n/vavai/riv/zamer	Parazitismus a parazito-hostitelské vztahy na organismální, buněčné a molekulové úrovni EKOLOGICKÉ, EVOLUČNÍ A EXPERIMENTÁLNĚ BIOLOGICKÉ PŘÍSTUPY KE STUDIU VZNIKU A VÝZNAMU BIODIVERZITY
issn	0264-410X
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.vaccine.2010.02.008

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