About: Interaction between Drosophila bZIP proteins Atf3 and Jun prevents replacement of epithelial cells during metamorphosis

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About: Interaction between Drosophila bZIP proteins Atf3 and Jun prevents replacement of epithelial cells during metamorphosis Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Animal development involves movements and fusions of epithelia. During metamorphosis of Drosophila, the precursor cells of abdominal epidermis (histoblasts) divide and migrate while replacing larval epidermal cells (LECs), which must depart from the epithelium to allow histoblast fusion and formation of the adult epidermis. Regulation of this morphogenetic cell replacement is unclear. We have found that temporally misregulated activity of the transcription factor Atf3 prevents LEC extrusion by interfering with the Rho signaling, leading to increased adhesiveness of LECs that consequently obstruct the closure of the adult abdominal epithelium. To elicit this effect, Atf3 requires its binding partner Jun. Although dimerization between the two important regulatory bZIP proteins has been well-established in mammalian cell lines, our data for the first time demonstrate a developmental function for the Jun-Atf3 complex in vivo. Animal development involves movements and fusions of epithelia. During metamorphosis of Drosophila, the precursor cells of abdominal epidermis (histoblasts) divide and migrate while replacing larval epidermal cells (LECs), which must depart from the epithelium to allow histoblast fusion and formation of the adult epidermis. Regulation of this morphogenetic cell replacement is unclear. We have found that temporally misregulated activity of the transcription factor Atf3 prevents LEC extrusion by interfering with the Rho signaling, leading to increased adhesiveness of LECs that consequently obstruct the closure of the adult abdominal epithelium. To elicit this effect, Atf3 requires its binding partner Jun. Although dimerization between the two important regulatory bZIP proteins has been well-established in mammalian cell lines, our data for the first time demonstrate a developmental function for the Jun-Atf3 complex in vivo. (en)
Title	Interaction between Drosophila bZIP proteins Atf3 and Jun prevents replacement of epithelial cells during metamorphosis Interaction between Drosophila bZIP proteins Atf3 and Jun prevents replacement of epithelial cells during metamorphosis (en)
skos:prefLabel	Interaction between Drosophila bZIP proteins Atf3 and Jun prevents replacement of epithelial cells during metamorphosis Interaction between Drosophila bZIP proteins Atf3 and Jun prevents replacement of epithelial cells during metamorphosis (en)
skos:notation	RIV/60077344:_____/10:00338123!RIV10-MSM-60077344
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(2B06129), Z(AV0Z50070508)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Sekyrová, Petra Jindra, Marek
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	264372
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/10:00338123
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	epithelial cell replacement; cell adhesion; epidermis (en)
http://linked.open.../riv/klicoveSlovo	epidermis epithelial cell replacement cell adhesion
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[C52FD6B6AEB9]
http://linked.open...i/riv/nazevZdroje	Development
http://linked.open...in/vavai/riv/obor	EA
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Model organisms as a key to the understanding of functions of disease-related human genes
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	137
http://linked.open...iv/tvurceVysledku	Jindra, Marek Uhlířová, M. Sekyrová, Petra Bohmann, D.
http://linked.open...ain/vavai/riv/wos	000272977200018
http://linked.open...n/vavai/riv/zamer	Study of the regulation of insect organism, dynamics of insect populations and function of insects in ecosystems
issn	0950-1991
number of pages	10 (xsd:int)

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