About: Nuclear receptor NHR-25 interacts with Wnt/β-catenin signaling to direct differentiation of the C. elegans T cell

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About: Nuclear receptor NHR-25 interacts with Wnt/β-catenin signaling to direct differentiation of the C. elegans T cell Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We show that an impaired function of the nuclear receptor NHR-25 abolishes differentiation of the neural T cell lineage similarly to mutations in Wnt/β-catenin asymmetry signaling pathwaycomponents. By means of genetic interactionwe demonstrate that NHR-25 cooperates with the Wnt/β-catenin pathway and with a parallel RUNX signaling to establish the correct fate of T cell daughters. Strikingly, the positive interaction between NHR-25 and Wnt/ catenin signaling in the T cell has an opposite character than in the C. elegans somatic gonad, where NHR-25 was shown to antagonize a β-catenin pathway. We show that an impaired function of the nuclear receptor NHR-25 abolishes differentiation of the neural T cell lineage similarly to mutations in Wnt/β-catenin asymmetry signaling pathwaycomponents. By means of genetic interactionwe demonstrate that NHR-25 cooperates with the Wnt/β-catenin pathway and with a parallel RUNX signaling to establish the correct fate of T cell daughters. Strikingly, the positive interaction between NHR-25 and Wnt/ catenin signaling in the T cell has an opposite character than in the C. elegans somatic gonad, where NHR-25 was shown to antagonize a β-catenin pathway. (en)
Title	Nuclear receptor NHR-25 interacts with Wnt/β-catenin signaling to direct differentiation of the C. elegans T cell Nuclear receptor NHR-25 interacts with Wnt/β-catenin signaling to direct differentiation of the C. elegans T cell (en)
skos:prefLabel	Nuclear receptor NHR-25 interacts with Wnt/β-catenin signaling to direct differentiation of the C. elegans T cell Nuclear receptor NHR-25 interacts with Wnt/β-catenin signaling to direct differentiation of the C. elegans T cell (en)
skos:notation	RIV/60077344:_____/09:00336504!RIV10-MSM-60077344
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(2B06129), P(GA204/07/0948), P(GD204/09/H058), Z(AV0Z50070508), Z(AV0Z60220518)
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Hajdušková, Martina Asahina, Masako Jindra, Marek
http://linked.open.../riv/druhVysledku	O - Ostatní výsledky nezařaditelné do žádného z výše uvedených druhů výsledku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	330170
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/09:00336504
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Caenorhabditis elegans; asymmetric cell divisions; cell differentiation (en)
http://linked.open.../riv/klicoveSlovo	asymmetric cell divisions cell differentiation Caenorhabditis elegans
http://linked.open...ontrolniKodProRIV	[7CE97C9528C0]
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Model organisms as a key to the understanding of functions of disease-related human genes Intercellular signalling in development and disease Crosstalk between nuclear receptor and Wnt signaling in C. elegans
http://linked.open...UplatneniVysledku	2009
http://linked.open...iv/tvurceVysledku	Jindra, Marek Asahina, Masako Hajdušková, Martina Herman, M. A.
http://linked.open...n/vavai/riv/zamer	Study of the regulation of insect organism, dynamics of insect populations and function of insects in ecosystems Parazitismus a parazito-hostitelské vztahy na organismální, buněčné a molekulové úrovni

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