About: The nuclear receptor NHR-25 cooperates with the Wnt/ .beta.-catenin asymmetry pathway to control differentiation of the T seam cell in C. elegans

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: The nuclear receptor NHR-25 cooperates with the Wnt/ .beta.-catenin asymmetry pathway to control differentiation of the T seam cell in C. elegans Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Asymmetric cell divisions produce cells with distinct developmental fates, thus allowing differentiation of various tissues. Caenorhabditis elegans is extensively used to study cell fate determination, since its development relies heavily on asymmetric cell divisions. Differentiation of the epidermal cell T depends on its proper polarity that is established by the Wnt/.beta.-catenin asymmetry pathway. We show that the asymmetry of T cell division requires NHR-25, an evolutionarily conserved nuclear receptor. NHR-25 ensures the neural fate of the T cell lineage in cooperation with the Wnt/.beta.-catenin signaling. Loss of NHR-25 enhances the impact of mutated effectors of this pathway, POP-1/TCF and SYS-1/.beta.-catenin, on the T cell polarity, while it suppresses the effect of the same mutations on asymmetric division of the somatic gonad precursor cells. Therefore, our findings define NHR-25 as a versatile modulator of Wnt/.beta.-catenin signaling to govern correct cell fate decision. Asymmetric cell divisions produce cells with distinct developmental fates, thus allowing differentiation of various tissues. Caenorhabditis elegans is extensively used to study cell fate determination, since its development relies heavily on asymmetric cell divisions. Differentiation of the epidermal cell T depends on its proper polarity that is established by the Wnt/.beta.-catenin asymmetry pathway. We show that the asymmetry of T cell division requires NHR-25, an evolutionarily conserved nuclear receptor. NHR-25 ensures the neural fate of the T cell lineage in cooperation with the Wnt/.beta.-catenin signaling. Loss of NHR-25 enhances the impact of mutated effectors of this pathway, POP-1/TCF and SYS-1/.beta.-catenin, on the T cell polarity, while it suppresses the effect of the same mutations on asymmetric division of the somatic gonad precursor cells. Therefore, our findings define NHR-25 as a versatile modulator of Wnt/.beta.-catenin signaling to govern correct cell fate decision. (en)
Title	The nuclear receptor NHR-25 cooperates with the Wnt/ .beta.-catenin asymmetry pathway to control differentiation of the T seam cell in C. elegans The nuclear receptor NHR-25 cooperates with the Wnt/ .beta.-catenin asymmetry pathway to control differentiation of the T seam cell in C. elegans (en)
skos:prefLabel	The nuclear receptor NHR-25 cooperates with the Wnt/ .beta.-catenin asymmetry pathway to control differentiation of the T seam cell in C. elegans The nuclear receptor NHR-25 cooperates with the Wnt/ .beta.-catenin asymmetry pathway to control differentiation of the T seam cell in C. elegans (en)
skos:notation	RIV/60077344:_____/09:00334921!RIV10-MSM-60077344
http://linked.open...avai/riv/aktivita	P V Z
http://linked.open...avai/riv/aktivity	P(2B06129), P(GA204/07/0948), P(GD204/09/H058), V, Z(AV0Z50070508), Z(AV0Z60220518)
http://linked.open...iv/cisloPeriodika	17
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Hajdušková, Martina Asahina, Masako Jindra, Marek
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	330169
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/09:00334921
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	nuclear receptor; Wnt/.beta.-catenin signaling; Caenorhabditis elegans (en)
http://linked.open.../riv/klicoveSlovo	Wnt/.beta.-catenin signaling nuclear receptor Caenorhabditis elegans
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[347BA8B909F9]
http://linked.open...i/riv/nazevZdroje	Journal of Cell Science
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Model organisms as a key to the understanding of functions of disease-related human genes Intercellular signalling in development and disease Crosstalk between nuclear receptor and Wnt signaling in C. elegans
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	122
http://linked.open...iv/tvurceVysledku	Jindra, Marek Asahina, Masako Hajdušková, Martina Herman, M. A.
http://linked.open...ain/vavai/riv/wos	000269122000005
http://linked.open...n/vavai/riv/zamer	Study of the regulation of insect organism, dynamics of insect populations and function of insects in ecosystems Parazitismus a parazito-hostitelské vztahy na organismální, buněčné a molekulové úrovni
issn	0021-9533
number of pages	10 (xsd:int)

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 49 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software