About: Evolution of the serum resistance-associated SRA gene in African trypanosomes

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About: Evolution of the serum resistance-associated SRA gene in African trypanosomes Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Serum resistence-associated (SRA) protein, a protein unique for Trypanosoma brucei rhodesiense, is responsible for resistance of this parasite to the lysis by normal human serum (NHS) and is a vital molecular marker to distinguish this species from other African trypanosomes. We cloned and sequenced the SRA basic copy (SRAbc) gene from T. b. rhodesiense and related species and found that this gene is confined to the subgenus Trypanozoon. The average 82% identity among the sequenced SRAbc genes indicated that they may have a common origin and are highly conserved. Since SRAbc coexists in the T rhodesiense genome with SRA, we propose that SRAbc might be the %22donor VSG%22, which after duplication became inserted into the expression site by recombination. Under natural selection, SRAbc could reform into SRA following mosaic formation. Serum resistence-associated (SRA) protein, a protein unique for Trypanosoma brucei rhodesiense, is responsible for resistance of this parasite to the lysis by normal human serum (NHS) and is a vital molecular marker to distinguish this species from other African trypanosomes. We cloned and sequenced the SRA basic copy (SRAbc) gene from T. b. rhodesiense and related species and found that this gene is confined to the subgenus Trypanozoon. The average 82% identity among the sequenced SRAbc genes indicated that they may have a common origin and are highly conserved. Since SRAbc coexists in the T rhodesiense genome with SRA, we propose that SRAbc might be the %22donor VSG%22, which after duplication became inserted into the expression site by recombination. Under natural selection, SRAbc could reform into SRA following mosaic formation. (en)
Title	Evolution of the serum resistance-associated SRA gene in African trypanosomes Evolution of the serum resistance-associated SRA gene in African trypanosomes (en)
skos:prefLabel	Evolution of the serum resistance-associated SRA gene in African trypanosomes Evolution of the serum resistance-associated SRA gene in African trypanosomes (en)
skos:notation	RIV/60077344:_____/09:00334919!RIV10-MSM-60077344
http://linked.open...avai/riv/aktivita	P V Z
http://linked.open...avai/riv/aktivity	P(2B06129), V, Z(AV0Z60220518)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Lukeš, Julius
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	313987
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/09:00334919
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	SRA; SRAbc; evolution; African trypanosomes (en)
http://linked.open.../riv/klicoveSlovo	evolution African trypanosomes SRA SRAbc
http://linked.open...odStatuVydavatele	CN - Čínská lidová republika
http://linked.open...ontrolniKodProRIV	[94D1EDBAAED4]
http://linked.open...i/riv/nazevZdroje	Chinese Science Bulletin
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Model organisms as a key to the understanding of functions of disease-related human genes
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	54
http://linked.open...iv/tvurceVysledku	Lukeš, Julius Lai, D. H. Lun, Z. R. Wang, Q.P.
http://linked.open...ain/vavai/riv/wos	000264842600022
http://linked.open...n/vavai/riv/zamer	Parazitismus a parazito-hostitelské vztahy na organismální, buněčné a molekulové úrovni
issn	1001-6538
number of pages	4 (xsd:int)

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