About: Knockdown of proteins involved in iron metabolism limits tick reproduction and development

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We have characterized a new secreted ferritin (Fer2) and an iron regulatory protein (IRP1) from the hard tick, Ixodes ricinus, and have demonstrated their relationship to a previously described tick intracellular ferritin (Fer1). Using RNA interference, we have proved that Fer2 plays a role as a transporter of non-heme iron from the tick gut to the periheral tissues. Knockdown of Fer2 dramatically impairs the ability of ticks to feed, thus making Fer2 a promising candidate for development of an efficient anti-tick vaccine. We have characterized a new secreted ferritin (Fer2) and an iron regulatory protein (IRP1) from the hard tick, Ixodes ricinus, and have demonstrated their relationship to a previously described tick intracellular ferritin (Fer1). Using RNA interference, we have proved that Fer2 plays a role as a transporter of non-heme iron from the tick gut to the periheral tissues. Knockdown of Fer2 dramatically impairs the ability of ticks to feed, thus making Fer2 a promising candidate for development of an efficient anti-tick vaccine. (en)
Title	Knockdown of proteins involved in iron metabolism limits tick reproduction and development Knockdown of proteins involved in iron metabolism limits tick reproduction and development (en)
skos:prefLabel	Knockdown of proteins involved in iron metabolism limits tick reproduction and development Knockdown of proteins involved in iron metabolism limits tick reproduction and development (en)
skos:notation	RIV/60077344:_____/09:00327046!RIV10-MSM-60077344
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(IAA600220603), P(LC06009), P(LC07032), Z(AV0Z50070508), Z(AV0Z60220518), Z(MSM6007665801)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Kopáček, Petr Sojka, Daniel Šauman, Ivo Burešová, Veronika Hajdušek, Ondřej Franta, Zdeněk
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	321917
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/09:00327046
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	tick ferritin; iron metabolism; RNA interference (en)
http://linked.open.../riv/klicoveSlovo	tick ferritin RNA interference iron metabolism
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[D29E6CEC04AA]
http://linked.open...i/riv/nazevZdroje	Proceedings of the National Academy of Sciences of the United States of America
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	8 (xsd:int)
http://linked.open...vavai/riv/projekt	Centre for molecular ecology of vectors and pathogens Center for Functional Genetics The role of tick alpha-2-macroglobulin in pathogen transmission by the hard tick Ixodes ricinus
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	106
http://linked.open...iv/tvurceVysledku	Kopáček, Petr Šauman, Ivo Sojka, Daniel Burešová, Veronika Franta, Zdeněk Hajdušek, Ondřej Grubhoffer, L. Winzerling, J.
http://linked.open...ain/vavai/riv/wos	000262831600016
http://linked.open...n/vavai/riv/zamer	Study of the regulation of insect organism, dynamics of insect populations and function of insects in ecosystems Parazitismus a parazito-hostitelské vztahy na organismální, buněčné a molekulové úrovni EKOLOGICKÉ, EVOLUČNÍ A EXPERIMENTÁLNĚ BIOLOGICKÉ PŘÍSTUPY KE STUDIU VZNIKU A VÝZNAMU BIODIVERZITY
issn	0027-8424
number of pages	6 (xsd:int)

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