About: Enhancement of T cell-mediated and humoral immunity of beta-glucuronidase-based DNA vaccines against HPV16 E7 oncoprotein

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About: Enhancement of T cell-mediated and humoral immunity of beta-glucuronidase-based DNA vaccines against HPV16 E7 oncoprotein Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	V této práci jsme se pokusili zlepšit imunogenitu na GUS založené anti-E7 vakcíny zvýšením rovnovážné koncentrace tohoto fúzního proteinu. S 5' koncem GUS jsme fuzovali deleční mutanty E7GGG a kodonově optimalizovaný E7GGG, s 5' koncem GUS pak nezměněný E7GGG. Dále jsme mutovali iniciační kodon genu GUS v konstruktu E7GGG.GUS, neboť produktem tohoto fúzního genu byl samotný protein GUS. (cs) In this study, we attempted to improve immunogenicity of the GUS-based anti-E7 vaccines by increasing the steady-state level of fusion proteins. We fused deletion mutants of E7GGG and codon-optimized E7GGG with the 5'-terminus of GUS and unaltered E7GGG with the 3'-terminus of GUS. Furthermore, we mutated the initiation codon of the GUS gene in the E7GGG.GUS construct, as GUS alone was produced from this fusion gene. In this study, we attempted to improve immunogenicity of the GUS-based anti-E7 vaccines by increasing the steady-state level of fusion proteins. We fused deletion mutants of E7GGG and codon-optimized E7GGG with the 5'-terminus of GUS and unaltered E7GGG with the 3'-terminus of GUS. Furthermore, we mutated the initiation codon of the GUS gene in the E7GGG.GUS construct, as GUS alone was produced from this fusion gene. (en)
Title	Enhancement of T cell-mediated and humoral immunity of beta-glucuronidase-based DNA vaccines against HPV16 E7 oncoprotein Zvýšení T buňkami zprostředkované a humorální imunity proti onkoproteinu E7 z HPV DNA vakcínou založenou na beta-glucuronidáze (cs) Enhancement of T cell-mediated and humoral immunity of beta-glucuronidase-based DNA vaccines against HPV16 E7 oncoprotein (en)
skos:prefLabel	Enhancement of T cell-mediated and humoral immunity of beta-glucuronidase-based DNA vaccines against HPV16 E7 oncoprotein Zvýšení T buňkami zprostředkované a humorální imunity proti onkoproteinu E7 z HPV DNA vakcínou založenou na beta-glucuronidáze (cs) Enhancement of T cell-mediated and humoral immunity of beta-glucuronidase-based DNA vaccines against HPV16 E7 oncoprotein (en)
skos:notation	RIV/60077344:_____/08:00321729!RIV09-GA0-60077344
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA521/05/2092), P(GD310/05/H533), P(NR9246), Z(AV0Z50510513)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Vlasák, Josef
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	366264
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/08:00321729
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	immunogenicity; anti-E7 vaccines (en)
http://linked.open.../riv/klicoveSlovo	immunogenicity anti-E7 vaccines
http://linked.open...odStatuVydavatele	GR - Řecká republika
http://linked.open...ontrolniKodProRIV	[A2632AFE6146]
http://linked.open...i/riv/nazevZdroje	International Journal of Oncology
http://linked.open...in/vavai/riv/obor	FD
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Study of infectious diseases and their causative agents Development of anti-tumor DNA vaccines based on fusion of immunogen with E. coli beta-glucuronidase and enhancement of their effect by stimulation of non-specific immunity Plant production of human papillomavirus proteins and immunogenic properties of transgenic plant tissues
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	33
http://linked.open...iv/tvurceVysledku	Vlasák, Josef Dušková, M. Ludvíková, V. Šmahel, M. Pokorná, D. Poláková, I.
http://linked.open...ain/vavai/riv/wos	000257276200010
http://linked.open...n/vavai/riv/zamer	Výzkum struktury genetické informace rostlin a jejich patogenů na molekulární úrovni, indukce a analýza cílených změn genomu a plastomu a studium fotosyntetických procesů a projevů dědičnosti v interakci s prostředím a patogeny
issn	1019-6439
number of pages	10 (xsd:int)

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