About: The import and function of diatom and plant frataxins in the mitochondrion of Trypanosoma brucei

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About: The import and function of diatom and plant frataxins in the mitochondrion of Trypanosoma brucei Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Frataxin is a conserved mitochondrial protein, almost universally present in prokaryotes and eukaryotes, where it is implicated in Fe-S cluster assembly and several other processes. Here we show that frataxins from the diatom Thalassiosira pseudonana and the plant Arabidopsis thaliana are efficiently targeted and processed in the mitochondrion of the evolutionary distant excavate kinetoplastid flagellate Trypanosoma brucei. Moreover, both heterologous frataxins are able to rescue a lethal deficiency for T. brucei frataxin. Frataxin is a conserved mitochondrial protein, almost universally present in prokaryotes and eukaryotes, where it is implicated in Fe-S cluster assembly and several other processes. Here we show that frataxins from the diatom Thalassiosira pseudonana and the plant Arabidopsis thaliana are efficiently targeted and processed in the mitochondrion of the evolutionary distant excavate kinetoplastid flagellate Trypanosoma brucei. Moreover, both heterologous frataxins are able to rescue a lethal deficiency for T. brucei frataxin. (en) Frataxin je konzervovaný mitochondriální protein, všudypřítomný u prokaryot a eukaryot, kde se zúčastňuje tvorby Fe-S klasterů a dalších procesů. V této práci ukazujeme, že frataxin z rozsivky Thalassiosira pseudonana a rostliny Arabidopsis thaliana je efektivně vnášen a upravován v mitochondrii evolučně vzdáleného kinetoplastidového bičíkovce Trypanosoma brucei. Navíc byly oba heterologní frataxiny schopny zachránit smrtelnou deficienci frataxinu v T. brucei. (cs)
Title	The import and function of diatom and plant frataxins in the mitochondrion of Trypanosoma brucei The import and function of diatom and plant frataxins in the mitochondrion of Trypanosoma brucei (en) Import a funkce rozsivkového a rostlinného frataxinu v mitochondrii Trypanosoma brucei (cs)
skos:prefLabel	The import and function of diatom and plant frataxins in the mitochondrion of Trypanosoma brucei The import and function of diatom and plant frataxins in the mitochondrion of Trypanosoma brucei (en) Import a funkce rozsivkového a rostlinného frataxinu v mitochondrii Trypanosoma brucei (cs)
skos:notation	RIV/60077344:_____/08:00318325!RIV09-GA0-60077344
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(2B06129), P(GA204/06/1558), P(IAA500960705), P(LC07032), Z(AV0Z60220518)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Vávrová, Zuzana Lukeš, Julius Long, Shaojun
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	371658
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/08:00318325
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	frataxin; mitochondrion; Trypanosoma; diatom; evolutionary conservativeness; import (en)
http://linked.open.../riv/klicoveSlovo	mitochondrion Trypanosoma diatom import frataxin evolutionary conservativeness
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[3F0F23401436]
http://linked.open...i/riv/nazevZdroje	Molecular and Biochemical Parasitology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	Model organisms as a key to the understanding of functions of disease-related human genes Center for Functional Genetics Functional analysis of mitochondrial proteins in Trypanosoma brucei The role of Trypanosoma brucei RNA binding proteins in mitochondrial transcript processing.
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	162
http://linked.open...iv/tvurceVysledku	Lukeš, Julius Vávrová, Zuzana Long, Shaojun
http://linked.open...ain/vavai/riv/wos	000260547900011
http://linked.open...n/vavai/riv/zamer	Parazitismus a parazito-hostitelské vztahy na organismální, buněčné a molekulové úrovni
issn	0166-6851
number of pages	5 (xsd:int)

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