About: Broad-Complex acts downstream of Met in juvenile hormone signaling to coordinate primitive holometabolan metamorphosis

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About: Broad-Complex acts downstream of Met in juvenile hormone signaling to coordinate primitive holometabolan metamorphosis Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Juvenile hormone (JH) prevents metamorphosis of insect larvae to pupae and adults, however, a molecular mechanism of JH action remains unknown. By using RNA interference in the red flour beetle Tribolium castaneum, we discovered that the transcription factor Broad-Complex (BR-C) coordinates the transition between larval, pupal and adult insect stages during metamorphosis. We further showed that JH regulates metamorphosis by altering the expression of the BR-C gene through the Methoprene-tolerant (Met) protein. This study for the first time implicated Met in JH-dependent regulation of a gene that is required for metamorphosis. Juvenile hormone (JH) prevents metamorphosis of insect larvae to pupae and adults, however, a molecular mechanism of JH action remains unknown. By using RNA interference in the red flour beetle Tribolium castaneum, we discovered that the transcription factor Broad-Complex (BR-C) coordinates the transition between larval, pupal and adult insect stages during metamorphosis. We further showed that JH regulates metamorphosis by altering the expression of the BR-C gene through the Methoprene-tolerant (Met) protein. This study for the first time implicated Met in JH-dependent regulation of a gene that is required for metamorphosis. (en) Juvenilní hormon (JH) zabraňuje přeměně hmyzích larev na kukly a dospělce, avšak molekulární mechanismus působení JH zůstává neznámý. S využitím interference RNA u brouka Tribolium castaneum jsme zjistili, že transkripční faktor Broad-Complex (BR-C) koordinuje přeměnu mezi larvou, kuklou a dospělým stadiem hmyzu během metamorfosy. Dále jsme ukázali, že JH řídí metamorfosu tím, že mění expresi genu BR-C prostřednictvím proteinu Methoprene-tolerant (Met). Tato práce poprvé prokázala funkci Met v JH-závislé regulaci genu, nezbytného pro metamorfosu. (cs)
Title	Broad-Complex acts downstream of Met in juvenile hormone signaling to coordinate primitive holometabolan metamorphosis Broad-Complex acts downstream of Met in juvenile hormone signaling to coordinate primitive holometabolan metamorphosis (en) Gen Broad-Complex, řízený juvenilním hormonem prostřednictvím proteinu Met, koordinuje primitivní typ holometabolní metamorfosy (cs)
skos:prefLabel	Broad-Complex acts downstream of Met in juvenile hormone signaling to coordinate primitive holometabolan metamorphosis Broad-Complex acts downstream of Met in juvenile hormone signaling to coordinate primitive holometabolan metamorphosis (en) Gen Broad-Complex, řízený juvenilním hormonem prostřednictvím proteinu Met, koordinuje primitivní typ holometabolní metamorfosy (cs)
skos:notation	RIV/60077344:_____/08:00098991!RIV08-AV0-60077344
http://linked.open.../vavai/riv/strany	559;568
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(GA204/07/1032), P(IAA5007305), P(LC07032), S, Z(AV0Z50070508)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Konopová, Barbora Jindra, Marek
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	358523
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/08:00098991
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	metamorphosis; juvenile hormone; broad-complex (en)
http://linked.open.../riv/klicoveSlovo	juvenile hormone metamorphosis broad-complex
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[725641E6CFD8]
http://linked.open...i/riv/nazevZdroje	Development
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Genetic analysis of circadian and developmental genes in a new insect model Center for Functional Genetics Steroid signaling in insects: classical and new genetic approaches
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	135
http://linked.open...iv/tvurceVysledku	Jindra, Marek Konopová, Barbora
http://linked.open...n/vavai/riv/zamer	Study of the regulation of insect organism, dynamics of insect populations and function of insects in ecosystems
issn	0950-1991
number of pages	10 (xsd:int)

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