| Attributes | Values |
|---|
| rdf:type
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| Description
| - Bránit předčasné metamorfose hmyzu je dlouho známou funkcí juvenilního hormonu (JH), avšak mechanismus účinku JH ani jeho receptor dosud neznáme. Nadějným kandidátem na roli receptoru JH je protein Methoprene-tolerant (Met), jehož ztráta u drosofily způsobuje resistenci k JH, ale nikoli předčasnou metamorfosu. S využitím modelu brouka Tribolium castaneum jsme ukázali, že umlčení homologního genu vede v souladu s anti-metamorfním účinkem JH k předčasnému kuklení a k dalším heterochronním znakům předčasné metamorfosy. Met tak v odpovědi na JH zprostředkuje správné načasování vstupu larvy do metamorfosy. Naše výsledky poprvé dokazují, že Met je nezbytný pro signalizaci JH během hmyzího vývoje, a podporují dosud zpochybňovanou funkci Met jako receptoru JH. (cs)
- Juvenile hormone (JH) has long been known to prevent precocious metamorphosis of insects. However, mechanisms of JH action and a JH receptor remain elusive. One promising candidate for the JH receptor role is the Methoprene-tolerant protein (Met), whose loss renders Drosophila resistant to JH but fails to cause precocious metamorphosis. By using the beetle model Tribolium castaneum, we show that silencing of the Met homolog leads to premature pupation and to other heterochronic phenotypes marking precocious metamorphosis, an effect consistent with the anti-metamorphic JH function. In response to JH, Met thus mediates proper timing of entry to metamorphosis. Our data for the first time demonstrate that Met is necessary for developmental JH signaling, and support the disputed role of Met in JH reception.
- Juvenile hormone (JH) has long been known to prevent precocious metamorphosis of insects. However, mechanisms of JH action and a JH receptor remain elusive. One promising candidate for the JH receptor role is the Methoprene-tolerant protein (Met), whose loss renders Drosophila resistant to JH but fails to cause precocious metamorphosis. By using the beetle model Tribolium castaneum, we show that silencing of the Met homolog leads to premature pupation and to other heterochronic phenotypes marking precocious metamorphosis, an effect consistent with the anti-metamorphic JH function. In response to JH, Met thus mediates proper timing of entry to metamorphosis. Our data for the first time demonstrate that Met is necessary for developmental JH signaling, and support the disputed role of Met in JH reception. (en)
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| Title
| - Juvenile hormone resistance gene Methoprene-tolerant controls entry into metamorphosis in the beetle Tribolium castaneum
- Gen resistence na Juvenilní hormon, Methoprene-tolerant, řídí u brouka Tribolium castaneum vstup do metamorfosy (cs)
- Juvenile hormone resistance gene Methoprene-tolerant controls entry into metamorphosis in the beetle Tribolium castaneum (en)
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| skos:prefLabel
| - Juvenile hormone resistance gene Methoprene-tolerant controls entry into metamorphosis in the beetle Tribolium castaneum
- Gen resistence na Juvenilní hormon, Methoprene-tolerant, řídí u brouka Tribolium castaneum vstup do metamorfosy (cs)
- Juvenile hormone resistance gene Methoprene-tolerant controls entry into metamorphosis in the beetle Tribolium castaneum (en)
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| skos:notation
| - RIV/60077344:_____/07:00085027!RIV08-AV0-60077344
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| http://linked.open.../vavai/riv/strany
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
| - P(IAA5007305), P(LC07032), S, Z(AV0Z50070508)
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/60077344:_____/07:00085027
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| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - insect metamorphosis; postembryonic development; endocryne regulation (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
| - Proceedings of the National Academy of Sciences of the United States of America
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
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| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Jindra, Marek
- Konopová, Barbora
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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