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rdf:type
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Description
| - Role protilátek v imunitní odpovědi na mikrosporidiózu byla studována pomocí anti-exospórové monoklonální protilátky (MAb) P5/H1 zaměřené proti povrchovým antigenům mikrosporidie Encephalitozoon cuniculi. Efektem MAb na mikrosporidiovou infekci in vivo bylo prodloužení přežívání CD4+ T lymfocyty rekonstituovaných, perorálně infikovaných a intraperitoneálně monoklonální protilátkou léčených SCID myší. MAb snižovala počet spor E. cuniculi v peritoneálních stěrech získaných post mortem. Tyto výsledky naznačují možnou roli protilátek v ochraně před perorálně získanou infekcí E. cuniculi. (cs)
- The role of antibodies in the immune response to microsporidiosis was studied using a novel anti-exospore monoclonal antibody (MAb) P5/H1, which recognizes surface antigens of Encephalitozoon cuniculi. The effect of the MAb on microsporidial infection in vivo was to prolong the survival of previously CD4+ reconstituted, perorally infected and intraperitoneally MAb-treated SCID mice. The MAb decreased the numbers of E. cuniculi spores in peritoneal smears obtained post mortem. These results suggest a possible role for antibodies in protection against perorally acquired E. cuniculi infection.
- The role of antibodies in the immune response to microsporidiosis was studied using a novel anti-exospore monoclonal antibody (MAb) P5/H1, which recognizes surface antigens of Encephalitozoon cuniculi. The effect of the MAb on microsporidial infection in vivo was to prolong the survival of previously CD4+ reconstituted, perorally infected and intraperitoneally MAb-treated SCID mice. The MAb decreased the numbers of E. cuniculi spores in peritoneal smears obtained post mortem. These results suggest a possible role for antibodies in protection against perorally acquired E. cuniculi infection. (en)
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Title
| - Antibodies enhance the protective effect of CD4+ T lymphocytes in SCID mice perorally infected with Encephalitozoon cuniculi
- Protilátky zvyšují ochranný efekt CD4+ T lymfocytů u SCID myší perorálně infikovaných Encephalitozoon cuniculi (cs)
- Antibodies enhance the protective effect of CD4+ T lymphocytes in SCID mice perorally infected with Encephalitozoon cuniculi (en)
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skos:prefLabel
| - Antibodies enhance the protective effect of CD4+ T lymphocytes in SCID mice perorally infected with Encephalitozoon cuniculi
- Protilátky zvyšují ochranný efekt CD4+ T lymfocytů u SCID myší perorálně infikovaných Encephalitozoon cuniculi (cs)
- Antibodies enhance the protective effect of CD4+ T lymphocytes in SCID mice perorally infected with Encephalitozoon cuniculi (en)
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skos:notation
| - RIV/60077344:_____/06:00048911!RIV07-AV0-60077344
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http://linked.open.../vavai/riv/strany
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(GD524/03/H133), P(GP524/03/D167), S, Z(AV0Z60220518)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/60077344:_____/06:00048911
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Encephalitozoon cuniculi; humoral immunity; SCID mice (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Salát, Jiří
- Sak, Bohumil
- Ditrich, Oleg
- Saková, Kamila
- Horká, Helena
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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