| Attributes | Values |
|---|
| rdf:type
| |
| Description
| - Gen námi dříve izolovaného lektinu - Dorinu M z plazmy klíšťáka Ornithodoros moubata byl klonován a sekvenován. Lokalizace pomocí imunofluorescenční konfoklní mikrospopie prokázala, že je Dorin M exprimován v hemocytech. Tkáňový expresní profil pomocí RT-PCR navíc prokázal jeho expresi i ve slinných žlázách. Aminokyselinová sekvene Dorinu M jasně prokázala jeho příbuznost s proteiny obsahujícími fibrinogenovou doménu a významnou podobnost s tachylektiny 5A a 5B z ostrorepa Tachypleus tridentatus. Protože tyto lektiny fungují při rozpoznávání cizích molekul v imunitním systému bezobratlých, předpokládáme obdobnou funkci Dorinu M v imunitě klíštěte a při přenosu patogenů tímto vektorem. (cs)
- A lectin, named Dorin M, previously isolated and characterized from the hemolymph plasma of the soft tick, Ornithodoros moubata, was cloned and sequenced. The immunofluorescence using confocal microscopy revealed that DorinMis produced in the tick hemocytes. The tissue-specific expression investigated by RT-PCR revealed that Dorin M, in addition to hemocytes, is significantly expressed in salivary glands. The derived amino-acid sequence clearly shows that Dorin M has a fibrinogen-like domain, and exhibited the most significant similarity with tachylectins 5A and 5B from a horseshoe crab, Tachypleus tridentatus. Since these lectins have been reported to function as non-self recognizing molecules, we believe that Dorin M may play a similar role in an innate immunity of the tick and, possibly, also in pathogen transmission by this vector.
- A lectin, named Dorin M, previously isolated and characterized from the hemolymph plasma of the soft tick, Ornithodoros moubata, was cloned and sequenced. The immunofluorescence using confocal microscopy revealed that DorinMis produced in the tick hemocytes. The tissue-specific expression investigated by RT-PCR revealed that Dorin M, in addition to hemocytes, is significantly expressed in salivary glands. The derived amino-acid sequence clearly shows that Dorin M has a fibrinogen-like domain, and exhibited the most significant similarity with tachylectins 5A and 5B from a horseshoe crab, Tachypleus tridentatus. Since these lectins have been reported to function as non-self recognizing molecules, we believe that Dorin M may play a similar role in an innate immunity of the tick and, possibly, also in pathogen transmission by this vector. (en)
|
| Title
| - The tick plasma lectin, Dorin M, is a fibrinogen-related molecule
- The tick plasma lectin, Dorin M, is a fibrinogen-related molecule (en)
- Klíštěcí plasmový lektin Dorin M je molekula podobná fibrinogenu (cs)
|
| skos:prefLabel
| - The tick plasma lectin, Dorin M, is a fibrinogen-related molecule
- The tick plasma lectin, Dorin M, is a fibrinogen-related molecule (en)
- Klíštěcí plasmový lektin Dorin M je molekula podobná fibrinogenu (cs)
|
| skos:notation
| - RIV/60077344:_____/06:00047744!RIV07-AV0-60077344
|
| http://linked.open.../vavai/riv/strany
| |
| http://linked.open...avai/riv/aktivita
| |
| http://linked.open...avai/riv/aktivity
| - P(GA206/00/0266), P(IAA6022001), P(IAA6022307), P(IAA6022701), Z(AV0Z50070508), Z(AV0Z50200510), Z(AV0Z60220518)
|
| http://linked.open...iv/cisloPeriodika
| |
| http://linked.open...vai/riv/dodaniDat
| |
| http://linked.open...aciTvurceVysledku
| |
| http://linked.open.../riv/druhVysledku
| |
| http://linked.open...iv/duvernostUdaju
| |
| http://linked.open...titaPredkladatele
| |
| http://linked.open...dnocenehoVysledku
| |
| http://linked.open...ai/riv/idVysledku
| - RIV/60077344:_____/06:00047744
|
| http://linked.open...riv/jazykVysledku
| |
| http://linked.open.../riv/klicovaSlova
| - lectin; Ornithodoros moubata; hemolymph (en)
|
| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - GB - Spojené království Velké Británie a Severního Irska
|
| http://linked.open...ontrolniKodProRIV
| |
| http://linked.open...i/riv/nazevZdroje
| - Insect Biochemistry and Molecular Biology
|
| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
| |
| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...vavai/riv/projekt
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Grubhoffer, Libor
- Kopáček, Petr
- Kovář, Vojtěch
- Man, Petr
- Šauman, Ivo
- Rego, Ryan O. M.
- Weise, C.
|
| http://linked.open...n/vavai/riv/zamer
| |
| issn
| |
| number of pages
| |
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