About: Genus Nostoc - a source of novel trypsin inhibitors

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	V extraktech připravených z 50 nově izolovaných kmenů sinic rodu Nostoc bylo identifikováno několik látek vykazujících silnou inhibiční aktivitu vůči enzymu trypsinu. Detailní produkční podmínky pro látku nalezenou v kmeni Nostoc sp., strain LUKEŠOVÁ 30/93 byly studovány a optimální fyziologické parametry (vliv růstové fáze, intenzity světla a kultivační teploty) byly pro tento kmen stanoveny. (cs) In extracts from fifty newly-isolated strains of the genus Nostoc, numerous new molecules showing a capacity for protease inhibition were identified. The production conditions of the most active molecule, found in the Nostoc sp., strain LUKEŠOVÁ 30/93, were studied in detail and the optimal physiological parameters (growth phase, light intensity and culture temperature) examined. The highest active compound concentration was usually found 3 days after inoculation in cultures grown under optimum conditions (light intensity 70 W.m-2 and temperature 25°C). Similar observations seemed to be found for the other strains examined in the study. As far as the trypsin-inhibiting secondary metabolites is concerned, we may thus conclude that we have found no dependency on cell growth phase, light intensity or temperature otheer than leading to optimum growth conditions. We propose that the production of the trypsin inhibitor is coincident with conditions under which the colony of the microorganism mostly prospers In extracts from fifty newly-isolated strains of the genus Nostoc, numerous new molecules showing a capacity for protease inhibition were identified. The production conditions of the most active molecule, found in the Nostoc sp., strain LUKEŠOVÁ 30/93, were studied in detail and the optimal physiological parameters (growth phase, light intensity and culture temperature) examined. The highest active compound concentration was usually found 3 days after inoculation in cultures grown under optimum conditions (light intensity 70 W.m-2 and temperature 25°C). Similar observations seemed to be found for the other strains examined in the study. As far as the trypsin-inhibiting secondary metabolites is concerned, we may thus conclude that we have found no dependency on cell growth phase, light intensity or temperature otheer than leading to optimum growth conditions. We propose that the production of the trypsin inhibitor is coincident with conditions under which the colony of the microorganism mostly prospers (en)
Title	Genus Nostoc - a source of novel trypsin inhibitors Rod Nostoc jako zdroj nových inhibitorů trypsinu. (cs) Genus Nostoc - a source of novel trypsin inhibitors (en)
skos:prefLabel	Genus Nostoc - a source of novel trypsin inhibitors Rod Nostoc jako zdroj nových inhibitorů trypsinu. (cs) Genus Nostoc - a source of novel trypsin inhibitors (en)
skos:notation	RIV/60076658:12640/08:00009971!RIV09-MSM-12640___
http://linked.open...avai/riv/aktivita	P V Z
http://linked.open...avai/riv/aktivity	P(ME 874), V, Z(AV0Z50200510), Z(AV0Z60660521)
http://linked.open...iv/cisloPeriodika	x
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Štys, Dalibor Kopecký, Jiří
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Jihočeská univerzita v Českých Budějovicích / Ústav fyzikální biologie
http://linked.open...dnocenehoVysledku	369186
http://linked.open...ai/riv/idVysledku	RIV/60076658:12640/08:00009971
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Cyanobacteria; Nostoc; trypsin inhibitors; LC/MS; peptides (en)
http://linked.open.../riv/klicoveSlovo	LC/MS Cyanobacteria Nostoc peptides trypsin inhibitors
http://linked.open...odStatuVydavatele	DE - Spolková republika Německo
http://linked.open...ontrolniKodProRIV	[BD3708292772]
http://linked.open...i/riv/nazevZdroje	Archiv für Hydrobiologie
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	http://linked.opendata.cz/resource/domain/vavai/projekt/ME%20874
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	127
http://linked.open...iv/tvurceVysledku	Kopecký, Jiří Lukešová, Alena Štys, Dalibor Drápalová, Petra
http://linked.open...n/vavai/riv/zamer	Microorganisms in Research and Biotechnology Relationships between the structure and function of decomposer food web in soil
issn	0003-9136
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	12640

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