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| Description
| - In vitro cultivated Atlantic salmon (Salmo salar L.), hepatocytes were incubated without or with a mixture of sesamin and episesamin in order to test for possible effects on lipid metabolism. Sesamin/episesamin exposure (0.05 mM, final concentration) led to increased elongation and desaturation of 14C 18:3n-3 to docosahexaenoic acid (14C 22:6n-3, DHA, P0.01) and down regulated gene expression of 6 and 5 desaturases compared to control treatment. Sesamin/episesamin further increased the hepatocytes capacity for fatty acid -oxidation of 14C 18:3n-3 (P0.01) to the 14C acid soluble products, acetate, malate and oxaloacetate, in agreement with an increased gene expression of carnitine palmitoyltransferase I. Also the gene expression of cluster of differentiation 36 was upregulated and the expression of scavenger receptor type B, peroxisome proliferator-activated receptors a and c were downregulated. The amount of triacylglycerols secreted by the cells tended to be lower in the sesamin/episesamin incubated
- In vitro cultivated Atlantic salmon (Salmo salar L.), hepatocytes were incubated without or with a mixture of sesamin and episesamin in order to test for possible effects on lipid metabolism. Sesamin/episesamin exposure (0.05 mM, final concentration) led to increased elongation and desaturation of 14C 18:3n-3 to docosahexaenoic acid (14C 22:6n-3, DHA, P0.01) and down regulated gene expression of 6 and 5 desaturases compared to control treatment. Sesamin/episesamin further increased the hepatocytes capacity for fatty acid -oxidation of 14C 18:3n-3 (P0.01) to the 14C acid soluble products, acetate, malate and oxaloacetate, in agreement with an increased gene expression of carnitine palmitoyltransferase I. Also the gene expression of cluster of differentiation 36 was upregulated and the expression of scavenger receptor type B, peroxisome proliferator-activated receptors a and c were downregulated. The amount of triacylglycerols secreted by the cells tended to be lower in the sesamin/episesamin incubated (en)
- In vitro kultivované hepatocyty lososa obecného (Salmo salar L.), byly inkubovány se směsí sezaminu a episezaminu pro zjištění možného vlivu na metabolismus lipidů. Přidáni sezaminu/episezaminu (0.05 mM, konečná koncentrace) vedlo ke zvýšení elongace a desaturace 14C 18:3n-3 na dokosahexaenovou kyselinu (14C 22:6n-3, DHA, P0.01) a snížení genové exprese 6 a 5 desaturásy v porovnání s kontrolou. Sezamin/episezamin zvýšil kapacitu hepatocytové -oxidace 14C 18:3n-3 (P0.01) na 14C produkty, acetát, malát and oxaloacetát, přičemž byla zvýšena genová exprese karnitin palmitoyltransferásy I. Zároveň byla zvýšena genová exprese klastru diferenciace 36 a exprese ?scavenger receptoru? typu B. Genová exprese PPAR a PPAR byla snížena. Množství triacylglycerolu sekretovaného buňkami bylo sníženo v hepatocytech inkubovaných za přítomnosti sezaminu/episezaminu v porovnání s kontrolními buňkami. Touto studií byl prokázán příznivý vliv sezaminu na metabolismus lipidů vedoucí ke zvýšené hladině DHA. Tento pozitivní efe (cs)
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| Title
| - Sesamin Increases Alpha-Linolenic Acid Conversion to Docosahexaenoic Acid in Atlantic Salmon (Salmo salar L.) Hepatocytes: Role of Altered Gene Expression
- Sezamin zvýšuje konverzi alfa-linolenové kyseliny na kyselinu dokosahexaenovou v hepatocytech lososa obecného (Salmo salar L.): Vliv na změnu genové exprese (cs)
- Sesamin Increases Alpha-Linolenic Acid Conversion to Docosahexaenoic Acid in Atlantic Salmon (Salmo salar L.) Hepatocytes: Role of Altered Gene Expression (en)
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| skos:prefLabel
| - Sesamin Increases Alpha-Linolenic Acid Conversion to Docosahexaenoic Acid in Atlantic Salmon (Salmo salar L.) Hepatocytes: Role of Altered Gene Expression
- Sezamin zvýšuje konverzi alfa-linolenové kyseliny na kyselinu dokosahexaenovou v hepatocytech lososa obecného (Salmo salar L.): Vliv na změnu genové exprese (cs)
- Sesamin Increases Alpha-Linolenic Acid Conversion to Docosahexaenoic Acid in Atlantic Salmon (Salmo salar L.) Hepatocytes: Role of Altered Gene Expression (en)
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| skos:notation
| - RIV/60076658:12610/08:00008924!RIV09-MSM-12610___
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...iv/cisloPeriodika
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/60076658:12610/08:00008924
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - Hepatocytes; sesamin; desaturation; -linolenic acid; docosahexaenoic acid (en)
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| http://linked.open.../riv/klicoveSlovo
| |
| http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...i/riv/nazevZdroje
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| http://linked.open...in/vavai/riv/obor
| |
| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
| |
| http://linked.open...UplatneniVysledku
| |
| http://linked.open...v/svazekPeriodika
| |
| http://linked.open...iv/tvurceVysledku
| - Žlábek, Vladimír
- Picková, Jana
- Trattner, Sofia
- Kamal-Eldin, A.
- Ruyter, B.
- Østbye, T. K.
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| http://linked.open...ain/vavai/riv/wos
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| http://linked.open...n/vavai/riv/zamer
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| issn
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| number of pages
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| http://localhost/t...ganizacniJednotka
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