About: Decomposition of cellular systems via causal relations

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Monolayer of living cells time development is the closest approximation to organ development and function. It inspired the computational approach of cellular automata and agent-based modeling. Yet, for living cell description this approach is seldom utilized. In this paper we address reasons why biochemical /molecular biology approach is so much more popular. We present the formal structure of stochastic systems theory for formal description of the cell culture experiment. We define phenomenological attributes of cell monolayer system as cells states assigned by the operator. As system variables we consider levels of metabolic fluxes in cell compartments and between them and states of intracellular signals. For the behavior of system variables we consider that of stable orbits in the state space which arise from movement in the confined intracellular space combined with chemical reactions. Recent theoretical studies indicate also that formation and maintenance of cell shapes may arise by similar mechanism. Bio-inspired computing has been a holy grail of computational theory since its eve. Recent developments in biological systems description open a question what is really meant by this term, how much the neural networks are related to neuron and cellular automata to cells. We address in this paper also the issue of reality of bio-inspired computing in production of adequate models and/or integration of living cell elements in the computational process. Monolayer of living cells time development is the closest approximation to organ development and function. It inspired the computational approach of cellular automata and agent-based modeling. Yet, for living cell description this approach is seldom utilized. In this paper we address reasons why biochemical /molecular biology approach is so much more popular. We present the formal structure of stochastic systems theory for formal description of the cell culture experiment. We define phenomenological attributes of cell monolayer system as cells states assigned by the operator. As system variables we consider levels of metabolic fluxes in cell compartments and between them and states of intracellular signals. For the behavior of system variables we consider that of stable orbits in the state space which arise from movement in the confined intracellular space combined with chemical reactions. Recent theoretical studies indicate also that formation and maintenance of cell shapes may arise by similar mechanism. Bio-inspired computing has been a holy grail of computational theory since its eve. Recent developments in biological systems description open a question what is really meant by this term, how much the neural networks are related to neuron and cellular automata to cells. We address in this paper also the issue of reality of bio-inspired computing in production of adequate models and/or integration of living cell elements in the computational process. (en)
Title	Decomposition of cellular systems via causal relations Decomposition of cellular systems via causal relations (en)
skos:prefLabel	Decomposition of cellular systems via causal relations Decomposition of cellular systems via causal relations (en)
skos:notation	RIV/60076658:12520/11:43884048!RIV13-MSM-12520___
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(ED2.1.00/01.0024), S, Z(MSM6007665808)
http://linked.open...iv/cisloPeriodika	Neuvedeno
http://linked.open...vai/riv/dodaniDat	2013
http://linked.open...aciTvurceVysledku	Urban, Jan Štys, Dalibor
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Jihočeská univerzita v Českých Budějovicích / Fakulta rybářství a ochrany vod
http://linked.open...dnocenehoVysledku	193063
http://linked.open...ai/riv/idVysledku	RIV/60076658:12520/11:43884048
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	relations; causal; via; systems; cellular; Decomposition (en)
http://linked.open.../riv/klicoveSlovo	systems causal cellular relations via Decomposition
http://linked.open...odStatuVydavatele	CZ - Česká republika
http://linked.open...ontrolniKodProRIV	[3D4D4E62AC29]
http://linked.open...i/riv/nazevZdroje	Materials Structure
http://linked.open...in/vavai/riv/obor	BO
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...vavai/riv/projekt	South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	18
http://linked.open...iv/tvurceVysledku	Urban, Jan Štys, Dalibor Levitner, T.
http://linked.open...n/vavai/riv/zamer	Fyzikální biologie -nové přístupy v biologickém výzkumu
issn	1211-5894
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	12520

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