About: Fatty acids and gene expression response to bioactive compounds in Atlantic salmon (Salmo salar L.) hepatocytes

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About: Fatty acids and gene expression response to bioactive compounds in Atlantic salmon (Salmo salar L.) hepatocytes Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	OBJECTIVES: Effects of bioactive compounds on expression of genes involved in lipid metabolism and fatty acid composition were investigated in Atlantic salmon (Salmo salar L.) primary hepatocytes. METHODS: Five treatments were investigated: I) genistein 0.005 mM, II) genistein 0.025 mM, III) lipoic acid 0.2 mM, IV) sesamin/episesamin 0.05 mM, V) sesamin 0.05 mM and compared to controls. The relative expression of genes involved in lipid homeostasis was analysed after 12h and 48h. RESULTS: Incubation with lipoic acid, sesamin and episesamin/sesamin for 48h had significant effect on all analysed genes involved in lipid uptake, -oxidation, elongation and desaturation, some effects were detected on the expression of peroxisome prolifertor-activated receptor (PPARs). Also effects on the fatty acid composition were found. CONCLUSION: The strongest effect of bioactive copounds on hepatocyte gene expression was detected after 48 hours. OBJECTIVES: Effects of bioactive compounds on expression of genes involved in lipid metabolism and fatty acid composition were investigated in Atlantic salmon (Salmo salar L.) primary hepatocytes. METHODS: Five treatments were investigated: I) genistein 0.005 mM, II) genistein 0.025 mM, III) lipoic acid 0.2 mM, IV) sesamin/episesamin 0.05 mM, V) sesamin 0.05 mM and compared to controls. The relative expression of genes involved in lipid homeostasis was analysed after 12h and 48h. RESULTS: Incubation with lipoic acid, sesamin and episesamin/sesamin for 48h had significant effect on all analysed genes involved in lipid uptake, -oxidation, elongation and desaturation, some effects were detected on the expression of peroxisome prolifertor-activated receptor (PPARs). Also effects on the fatty acid composition were found. CONCLUSION: The strongest effect of bioactive copounds on hepatocyte gene expression was detected after 48 hours. (en)
Title	Fatty acids and gene expression response to bioactive compounds in Atlantic salmon (Salmo salar L.) hepatocytes Fatty acids and gene expression response to bioactive compounds in Atlantic salmon (Salmo salar L.) hepatocytes (en)
skos:prefLabel	Fatty acids and gene expression response to bioactive compounds in Atlantic salmon (Salmo salar L.) hepatocytes Fatty acids and gene expression response to bioactive compounds in Atlantic salmon (Salmo salar L.) hepatocytes (en)
skos:notation	RIV/60076658:12520/11:43873483!RIV12-MSM-12520___
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(ED2.1.00/01.0024), S
http://linked.open...iv/cisloPeriodika	2
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Picková, Jana Mráz, Jan
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Jihočeská univerzita v Českých Budějovicích / Fakulta rybářství a ochrany vod
http://linked.open...dnocenehoVysledku	199417
http://linked.open...ai/riv/idVysledku	RIV/60076658:12520/11:43873483
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	genistein; lipoic acid; episesamin; elongation; desaturation; beta-oxidation (en)
http://linked.open.../riv/klicoveSlovo	beta-oxidation desaturation elongation episesamin genistein lipoic acid
http://linked.open...odStatuVydavatele	SE - Švédské království
http://linked.open...ontrolniKodProRIV	[33A5926C5244]
http://linked.open...i/riv/nazevZdroje	Neuroendocrinology Letters
http://linked.open...in/vavai/riv/obor	GL
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	South Bohemian Research Center of Aquaculture and Biodiversity of Hydrocenoses
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	32
http://linked.open...iv/tvurceVysledku	Mráz, Jan Picková, Jana Ruyter, Bente Schiller Vestergren, Anna Lotta Trattner, Sofia
issn	0172-780X
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	12520

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