About: Enzymatic alterations and RNA/DNA ratio in intestine of rcarbamazepineainbow trout, Oncorhynchus mykiss, induced by chronic exposure to carbamazepine

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About: Enzymatic alterations and RNA/DNA ratio in intestine of rcarbamazepineainbow trout, Oncorhynchus mykiss, induced by chronic exposure to carbamazepine Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We investigated the effect of long-term exposure to carbamazepine (CBZ) on the enzymatic alterations and RNA/DNA ratio in intestine tissue of rainbow trout. Fish were exposed to sublethal concentrations of CBZ (1.0 mu g/l, 0.2 or 2.0 mg/l) for 42 days. Digestive enzymes (proteolytic enzymes and amylase) and energy metabolic enzyme (Na+-K+-ATPase) and antioxidant enzymes (superoxide dismutase [SOD], catalase [CAT], glutathione peroxidase [GPx], and glutathione reductase [GR]) in fish intestine were measured. In addition, intestinal RNA/DNA ratio was determined after 42 days exposure. Carbamazepine exposure at 2.0 mg/l led to significantly inhibited (P < 0.05) activity of Na+-K+-ATPase. Activities of the antioxidant enzymes SOD, CAT, and GPx in CBZ-treated groups gradually increased at lower concentration of CBZ (1.0 mu g/l and 0.2 mg/l), then significantly inhibited (P < 0.05) at 2.0 mg/l. After 42 days, the RNA/DNA ratio in fish intestine was significantly lower (P < 0.05) in groups exposed t We investigated the effect of long-term exposure to carbamazepine (CBZ) on the enzymatic alterations and RNA/DNA ratio in intestine tissue of rainbow trout. Fish were exposed to sublethal concentrations of CBZ (1.0 mu g/l, 0.2 or 2.0 mg/l) for 42 days. Digestive enzymes (proteolytic enzymes and amylase) and energy metabolic enzyme (Na+-K+-ATPase) and antioxidant enzymes (superoxide dismutase [SOD], catalase [CAT], glutathione peroxidase [GPx], and glutathione reductase [GR]) in fish intestine were measured. In addition, intestinal RNA/DNA ratio was determined after 42 days exposure. Carbamazepine exposure at 2.0 mg/l led to significantly inhibited (P < 0.05) activity of Na+-K+-ATPase. Activities of the antioxidant enzymes SOD, CAT, and GPx in CBZ-treated groups gradually increased at lower concentration of CBZ (1.0 mu g/l and 0.2 mg/l), then significantly inhibited (P < 0.05) at 2.0 mg/l. After 42 days, the RNA/DNA ratio in fish intestine was significantly lower (P < 0.05) in groups exposed t (en)
Title	Enzymatic alterations and RNA/DNA ratio in intestine of rcarbamazepineainbow trout, Oncorhynchus mykiss, induced by chronic exposure to carbamazepine Enzymatic alterations and RNA/DNA ratio in intestine of rcarbamazepineainbow trout, Oncorhynchus mykiss, induced by chronic exposure to carbamazepine (en)
skos:prefLabel	Enzymatic alterations and RNA/DNA ratio in intestine of rcarbamazepineainbow trout, Oncorhynchus mykiss, induced by chronic exposure to carbamazepine Enzymatic alterations and RNA/DNA ratio in intestine of rcarbamazepineainbow trout, Oncorhynchus mykiss, induced by chronic exposure to carbamazepine (en)
skos:notation	RIV/60076658:12520/10:00011448!RIV11-MZP-12520___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(SP/2E7/229/07), Z(MSM6007665809)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Velíšek, Josef Máchová, Jana Randák, Tomáš Grabic, Roman Žlábek, Vladimír Li, Zhihua
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Jihočeská univerzita v Českých Budějovicích / Fakulta rybářství a ochrany vod
http://linked.open...dnocenehoVysledku	257344
http://linked.open...ai/riv/idVysledku	RIV/60076658:12520/10:00011448
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Residual pharmaceutical; Fish; Intestine; Digestive enzyme; Na+-K+-ATPase; Antioxidant enzyme; RNA/DNA ratio (en)
http://linked.open.../riv/klicoveSlovo	Digestive enzyme Residual pharmaceutical Fish Antioxidant enzyme RNA/DNA ratio Intestine Na+-K+-ATPase
http://linked.open...odStatuVydavatele	NL - Nizozemsko
http://linked.open...ontrolniKodProRIV	[FAE564C9D2FE]
http://linked.open...i/riv/nazevZdroje	Ecotoxicology
http://linked.open...in/vavai/riv/obor	GL
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Anthropogenic pressures on the status of soils, water resources and water ecosystems in the Czech part of the international basin of the Elbe River
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	19
http://linked.open...iv/tvurceVysledku	Grabic, Roman Li, Zhihua Máchová, Jana Randák, Tomáš Velíšek, Josef Žlábek, Vladimír
http://linked.open...ain/vavai/riv/wos	000277228600005
http://linked.open...n/vavai/riv/zamer	Biologické, enviromentální a chovatelské aspekty v rybářství
issn	0963-9292
number of pages	7 (xsd:int)
http://localhost/t...ganizacniJednotka	12520

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