About: Modulation of antioxidant defence system in brain of rainbow trout (Oncorhynchus mykiss) after chronic carbamazepine treatment

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About: Modulation of antioxidant defence system in brain of rainbow trout (Oncorhynchus mykiss) after chronic carbamazepine treatment Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	We investigated the effect of long-term exposure to carbamazepine (CBZ) on the antioxidant system in brain tissue of rainbow trout. Fish were exposed to sublethal concentrations of CBZ (1.0 μg/l, 0.2 mg/l or 2.0 mg/l) for 7, 21, and 42 days. Oxidative stress indices (lipid peroxidation [LPO]) and carbonyl protein [CP]) and enzymatic antioxidants (superoxide dismutase [SOD], catalase [CAT], glutathione peroxidase [GPx], and glutathione reductase [GR]) in fish brain were measured. In addition, non-enzymatic antioxidant (reduced glutathione [GSH]) was determined after 42 days exposure. Carbamazepine exposure at 0.2 mg/l led to significant increases (p<0.05) of LPO and CP after 42 days and, at 2.0 mg/l, after 21 days. Activity of the enzymatic antioxidants SOD, CAT, and GPx in CBZ-treated groups slightly increased during the first period (7 days). However, all measured antioxidant enzymes were significantly inhibited (p<0.05) at 0.2 mg/l exposure after 42 days and after 21 days at 2.0 mg/l. Aft We investigated the effect of long-term exposure to carbamazepine (CBZ) on the antioxidant system in brain tissue of rainbow trout. Fish were exposed to sublethal concentrations of CBZ (1.0 μg/l, 0.2 mg/l or 2.0 mg/l) for 7, 21, and 42 days. Oxidative stress indices (lipid peroxidation [LPO]) and carbonyl protein [CP]) and enzymatic antioxidants (superoxide dismutase [SOD], catalase [CAT], glutathione peroxidase [GPx], and glutathione reductase [GR]) in fish brain were measured. In addition, non-enzymatic antioxidant (reduced glutathione [GSH]) was determined after 42 days exposure. Carbamazepine exposure at 0.2 mg/l led to significant increases (p<0.05) of LPO and CP after 42 days and, at 2.0 mg/l, after 21 days. Activity of the enzymatic antioxidants SOD, CAT, and GPx in CBZ-treated groups slightly increased during the first period (7 days). However, all measured antioxidant enzymes were significantly inhibited (p<0.05) at 0.2 mg/l exposure after 42 days and after 21 days at 2.0 mg/l. Aft (en)
Title	Modulation of antioxidant defence system in brain of rainbow trout (Oncorhynchus mykiss) after chronic carbamazepine treatment Modulation of antioxidant defence system in brain of rainbow trout (Oncorhynchus mykiss) after chronic carbamazepine treatment (en)
skos:prefLabel	Modulation of antioxidant defence system in brain of rainbow trout (Oncorhynchus mykiss) after chronic carbamazepine treatment Modulation of antioxidant defence system in brain of rainbow trout (Oncorhynchus mykiss) after chronic carbamazepine treatment (en)
skos:notation	RIV/60076658:12520/10:00009994!RIV11-MZP-12520___
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(SP/2E7/229/07), Z(MSM6007665809)
http://linked.open...iv/cisloPeriodika	1
http://linked.open...vai/riv/dodaniDat	2011
http://linked.open...aciTvurceVysledku	Velíšek, Josef Máchová, Jana Randák, Tomáš Grabic, Roman Žlábek, Vladimír Li, Zhihua
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Jihočeská univerzita v Českých Budějovicích / Fakulta rybářství a ochrany vod
http://linked.open...dnocenehoVysledku	272329
http://linked.open...ai/riv/idVysledku	RIV/60076658:12520/10:00009994
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Oxidative stress; Fish; Brain damage; Residual pharmaceutical (en)
http://linked.open.../riv/klicoveSlovo	Brain damage Oxidative stress Residual pharmaceutical Fish
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[D400E995CB0D]
http://linked.open...i/riv/nazevZdroje	Comparative Biochemistry and Physiology C - Toxicology and Pharmacology
http://linked.open...in/vavai/riv/obor	GL
http://linked.open...ichTvurcuVysledku	6 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Anthropogenic pressures on the status of soils, water resources and water ecosystems in the Czech part of the international basin of the Elbe River
http://linked.open...UplatneniVysledku	2010
http://linked.open...v/svazekPeriodika	151
http://linked.open...iv/tvurceVysledku	Grabic, Roman Li, Zhihua Máchová, Jana Randák, Tomáš Velíšek, Josef Žlábek, Vladimír
http://linked.open...ain/vavai/riv/wos	000273152400017
http://linked.open...n/vavai/riv/zamer	Biologické, enviromentální a chovatelské aspekty v rybářství
issn	1532-0456
number of pages	5 (xsd:int)
http://localhost/t...ganizacniJednotka	12520

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