About: Modulation of porcine cytochrome P450 enzyme activities by surgical castration and immunocastration

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About: Modulation of porcine cytochrome P450 enzyme activities by surgical castration and immunocastration Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The present study aimed to evaluate some cytochrome P450 metabolic enzyme activities in hepatic microsomes prepared from entire male pigs (uncastrated pigs), surgically castrated pigs and pigs immunized against gonadotropin-releasing hormone (immunocastrated pigs). The activities of the following enzymes were measured: ethoxyresorufin O-deethylase (EROD, CYP1A1/1A2), methoxyresorufin O-deethylase (MROD, CYP1A2), pentoxyresorufin O-depentylase (PROD, CYP2B), coumarin hydroxylase (COH, CYP2A) and p-nitrophenol hydroxylase (PNPH, CYP2A/2E1). The total cytochrome P450 contents were not affected by either surgical or immunocastration. Hepatic microsomal activities for EROD, PROD, COH and PNPH were lower in entire male pigs compared with surgically castrated and immunocastrated pigs ( P,0.05). Surgically and immunocastrated male pigs were similar with respect to EROD, MROD, PROD and COH activities ( P.0.05), whereas surgically castrated pigs exhibited lower PNPH activity compared with immunocastrated pigs ( The present study aimed to evaluate some cytochrome P450 metabolic enzyme activities in hepatic microsomes prepared from entire male pigs (uncastrated pigs), surgically castrated pigs and pigs immunized against gonadotropin-releasing hormone (immunocastrated pigs). The activities of the following enzymes were measured: ethoxyresorufin O-deethylase (EROD, CYP1A1/1A2), methoxyresorufin O-deethylase (MROD, CYP1A2), pentoxyresorufin O-depentylase (PROD, CYP2B), coumarin hydroxylase (COH, CYP2A) and p-nitrophenol hydroxylase (PNPH, CYP2A/2E1). The total cytochrome P450 contents were not affected by either surgical or immunocastration. Hepatic microsomal activities for EROD, PROD, COH and PNPH were lower in entire male pigs compared with surgically castrated and immunocastrated pigs ( P,0.05). Surgically and immunocastrated male pigs were similar with respect to EROD, MROD, PROD and COH activities ( P.0.05), whereas surgically castrated pigs exhibited lower PNPH activity compared with immunocastrated pigs ( (en)
Title	Modulation of porcine cytochrome P450 enzyme activities by surgical castration and immunocastration Modulation of porcine cytochrome P450 enzyme activities by surgical castration and immunocastration (en)
skos:prefLabel	Modulation of porcine cytochrome P450 enzyme activities by surgical castration and immunocastration Modulation of porcine cytochrome P450 enzyme activities by surgical castration and immunocastration (en)
skos:notation	RIV/60076658:12520/09:00010321!RIV10-MSM-12520___
http://linked.open...avai/riv/aktivita	Z
http://linked.open...avai/riv/aktivity	Z(MSM6007665809)
http://linked.open...iv/cisloPeriodika	3
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Žlábek, Vladimír
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Jihočeská univerzita v Českých Budějovicích / Fakulta rybářství a ochrany vod
http://linked.open...dnocenehoVysledku	327185
http://linked.open...ai/riv/idVysledku	RIV/60076658:12520/09:00010321
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Castration; cytochrome P450; porcine liver microsomes; steroids (en)
http://linked.open.../riv/klicoveSlovo	steroids cytochrome P450 porcine liver microsomes Castration
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[505E029105E9]
http://linked.open...i/riv/nazevZdroje	Animal
http://linked.open...in/vavai/riv/obor	FB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...UplatneniVysledku	2009
http://linked.open...v/svazekPeriodika	9
http://linked.open...iv/tvurceVysledku	Žlábek, Vladimír Chen, G. Zamaratskaia, Galia Madej, A.
http://linked.open...ain/vavai/riv/wos	000268079600007
http://linked.open...n/vavai/riv/zamer	Biologické, enviromentální a chovatelské aspekty v rybářství
issn	1751-7311
number of pages	9 (xsd:int)
http://localhost/t...ganizacniJednotka	12520

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