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  • The temporal and spatial segregation of the two extra-embryonic cell lineages, trophectoderm and primitive endoderm (TE and PE respectively), from the pluripotent epiblast (EPI) during mammalian pre-implantation development are prerequisites for the successful implantation of the blastocyst. The mechanisms underlying these earliest stages of development remain a fertile topic for research and informed debate. In recent years novel roles for various transcription factors, polarity factors and signalling cascades have been uncovered. This mini-review seeks to summarise some of this work and to put it into the context of the regulative nature of early mammalian development and to highlight how the increasing evidence of naturally occurring asymmetries and heterogeneity in the embryo can bias specification of the distinct cell types of the blastocyst.
  • The temporal and spatial segregation of the two extra-embryonic cell lineages, trophectoderm and primitive endoderm (TE and PE respectively), from the pluripotent epiblast (EPI) during mammalian pre-implantation development are prerequisites for the successful implantation of the blastocyst. The mechanisms underlying these earliest stages of development remain a fertile topic for research and informed debate. In recent years novel roles for various transcription factors, polarity factors and signalling cascades have been uncovered. This mini-review seeks to summarise some of this work and to put it into the context of the regulative nature of early mammalian development and to highlight how the increasing evidence of naturally occurring asymmetries and heterogeneity in the embryo can bias specification of the distinct cell types of the blastocyst. (en)
Title
  • Developmental control of the early mammalian embryo: competition among heterogeneous cells that biases cell fate
  • Developmental control of the early mammalian embryo: competition among heterogeneous cells that biases cell fate (en)
skos:prefLabel
  • Developmental control of the early mammalian embryo: competition among heterogeneous cells that biases cell fate
  • Developmental control of the early mammalian embryo: competition among heterogeneous cells that biases cell fate (en)
skos:notation
  • RIV/60076658:12310/10:00011802!RIV11-MSM-12310___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • Z(MSM6007665801)
http://linked.open...iv/cisloPeriodika
  • 5
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
  • Bruce, Alexander William
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 254025
http://linked.open...ai/riv/idVysledku
  • RIV/60076658:12310/10:00011802
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • early mouse embryo; anterior visceral endoderm; primitive endoderm; extraembryonic ectoderm; preimplantation embryo; lineage segregation; gene-expression; 8-cell stage; stem-cells; trophectoderm (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • NL - Nizozemsko
http://linked.open...ontrolniKodProRIV
  • [49261A13B9CF]
http://linked.open...i/riv/nazevZdroje
  • Current Opinion in Genetics and Development
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 20
http://linked.open...iv/tvurceVysledku
  • Bruce, Alexander William
  • Zernicka-Goetz, Magdalena
http://linked.open...ain/vavai/riv/wos
  • 000282864300004
http://linked.open...n/vavai/riv/zamer
issn
  • 0959-437X
number of pages
http://localhost/t...ganizacniJednotka
  • 12310
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