About: Cell-autonomous roles of the ecdysoneless gene in Drosophila development and oogenesis

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About: Cell-autonomous roles of the ecdysoneless gene in Drosophila development and oogenesis Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Na buňce nezávislá role genu s mutací pro ekdyson ve vývoji Drosophily a oogenezi (cs) Steroid signaling underlies developmental processes in animals. Mutations that impair steroidogenesis in the fruit fly Drosophila melanogaster provide tools to dissect steroid hormone action genetically. The widely used temperature-sensitive mutation ecdysoneless(1) (ecd(1)) disrupts production of the steroid hormone ecdysone, and causes developmental and reproductive defects. These defects cannot be satisfactorily interpreted without analysis of the ecd gene. Here, we show that ecd encodes an as yet functionally undescribed protein that is conserved throughout eukaryotes. The ecd(1) conditional allele contains an amino acid substitution, whereas three non-conditional larval lethal mutations result in truncated Ecd proteins. Consistent with its role in steroid synthesis, Ecd is expressed in the ecdysone-producing larval ring gland. However, development of ecd-null early larval lethal mutants cannot be advanced by Ecd expression targeted to the ring gland or by hormone feeding. Cell-autonomous ecd func Steroid signaling underlies developmental processes in animals. Mutations that impair steroidogenesis in the fruit fly Drosophila melanogaster provide tools to dissect steroid hormone action genetically. The widely used temperature-sensitive mutation ecdysoneless(1) (ecd(1)) disrupts production of the steroid hormone ecdysone, and causes developmental and reproductive defects. These defects cannot be satisfactorily interpreted without analysis of the ecd gene. Here, we show that ecd encodes an as yet functionally undescribed protein that is conserved throughout eukaryotes. The ecd(1) conditional allele contains an amino acid substitution, whereas three non-conditional larval lethal mutations result in truncated Ecd proteins. Consistent with its role in steroid synthesis, Ecd is expressed in the ecdysone-producing larval ring gland. However, development of ecd-null early larval lethal mutants cannot be advanced by Ecd expression targeted to the ring gland or by hormone feeding. Cell-autonomous ecd func (en)
Title	Cell-autonomous roles of the ecdysoneless gene in Drosophila development and oogenesis Cell-autonomous roles of the ecdysoneless gene in Drosophila development and oogenesis (en) Na buňce nezávislá role genu s mutací pro ekdyson ve vývoji Drosophily a oogenezi (cs)
skos:prefLabel	Cell-autonomous roles of the ecdysoneless gene in Drosophila development and oogenesis Cell-autonomous roles of the ecdysoneless gene in Drosophila development and oogenesis (en) Na buňce nezávislá role genu s mutací pro ekdyson ve vývoji Drosophily a oogenezi (cs)
skos:notation	RIV/60076658:12310/04:00008656!RIV08-MSM-12310___
http://linked.open.../vavai/riv/strany	2715-2725
http://linked.open...avai/riv/aktivita	P V
http://linked.open...avai/riv/aktivity	P(IAA5007305), V
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Jindra, Marek
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Jihočeská univerzita v Českých Budějovicích / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	556984
http://linked.open...ai/riv/idVysledku	RIV/60076658:12310/04:00008656
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	steroid hormons; Ecdysone; ecdysoneless; imaginal disc; oogenesis; Drosophila (en)
http://linked.open.../riv/klicoveSlovo	oogenesis Drosophila Ecdysone ecdysoneless imaginal disc steroid hormons
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[5D5567E41F08]
http://linked.open...i/riv/nazevZdroje	Development
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Steroid signaling in insects: classical and new genetic approaches
http://linked.open...UplatneniVysledku	2004
http://linked.open...v/svazekPeriodika	131
http://linked.open...iv/tvurceVysledku	Jindra, Marek Gažiová, I. Bonnette, P. C. Henrich, V. C.
issn	0950-1991
number of pages	11 (xsd:int)
http://localhost/t...ganizacniJednotka	12310

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