About: Drosophila MBF1 is a co-activator for Tracheae Defective and contributes to the formation of tracheal and nervous systems.

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About: Drosophila MBF1 is a co-activator for Tracheae Defective and contributes to the formation of tracheal and nervous systems. Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Drosophila MBF1 je koaktivatorem dychacich defektu a prispiva k tvorbe dychaciho a nervoveho systemu (cs) During gene activation, the effect of binding of transcription factors to cis-acting DNA sequences is transmitted to RNA polymerase by means of co-activators. Although co-activators contribute to the efficiency of transcription, their developmental roles are poorly understood. We used Drosophila to conduct molecular and genetic dissection of an evolutionarily conserved but unique co-activator, Multiprotein Bridging Factor 1 (MBF1), in a multicellular organism. Through immunoprecipitation, MBF1 was found to form a ternary complex including MBF1, TATA-binding protein (TBP) and the bZIP protein Tracheae Defective (TDF)/Apontic. We have isolated a Drosophila mutant that lacks the mbf1 gene in which no stable association between TBP and TDF is detectable, and transcription of a TDF-dependent reporter gene is reduced by 80%. Although the null mutants of mbf1 are viable, tdf becomes haploinsufficient in mbf1-deficient background, causing severe lesions in tracheae and the central nervous system, similar to t During gene activation, the effect of binding of transcription factors to cis-acting DNA sequences is transmitted to RNA polymerase by means of co-activators. Although co-activators contribute to the efficiency of transcription, their developmental roles are poorly understood. We used Drosophila to conduct molecular and genetic dissection of an evolutionarily conserved but unique co-activator, Multiprotein Bridging Factor 1 (MBF1), in a multicellular organism. Through immunoprecipitation, MBF1 was found to form a ternary complex including MBF1, TATA-binding protein (TBP) and the bZIP protein Tracheae Defective (TDF)/Apontic. We have isolated a Drosophila mutant that lacks the mbf1 gene in which no stable association between TBP and TDF is detectable, and transcription of a TDF-dependent reporter gene is reduced by 80%. Although the null mutants of mbf1 are viable, tdf becomes haploinsufficient in mbf1-deficient background, causing severe lesions in tracheae and the central nervous system, similar to t (en)
Title	Drosophila MBF1 je koaktivatorem dychacich defektu a prispiva k tvorbe dychaciho a nervoveho systemu (cs) Drosophila MBF1 is a co-activator for Tracheae Defective and contributes to the formation of tracheal and nervous systems. Drosophila MBF1 is a co-activator for Tracheae Defective and contributes to the formation of tracheal and nervous systems. (en)
skos:prefLabel	Drosophila MBF1 je koaktivatorem dychacich defektu a prispiva k tvorbe dychaciho a nervoveho systemu (cs) Drosophila MBF1 is a co-activator for Tracheae Defective and contributes to the formation of tracheal and nervous systems. Drosophila MBF1 is a co-activator for Tracheae Defective and contributes to the formation of tracheal and nervous systems. (en)
skos:notation	RIV/60076658:12310/03:00008616!RIV08-MSM-12310___
http://linked.open.../vavai/riv/strany	719-728
http://linked.open...avai/riv/aktivita	P V Z
http://linked.open...avai/riv/aktivity	P(GA204/00/0811), V, Z(AV0Z5007907)
http://linked.open...iv/cisloPeriodika	4
http://linked.open...vai/riv/dodaniDat	2008
http://linked.open...aciTvurceVysledku	Jindra, Marek
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Jihočeská univerzita v Českých Budějovicích / Přírodovědecká fakulta
http://linked.open...dnocenehoVysledku	604487
http://linked.open...ai/riv/idVysledku	RIV/60076658:12310/03:00008616
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	TRANSCRIPTIONAL COACTIVATOR; GENE-EXPRESSION; BINDING PROTEIN; BOMBYX-MORI; IN-VIVO; CBP; COMPLEX; DIFFERENTIATION; BMFTZ-F1; SILKWORM (en)
http://linked.open.../riv/klicoveSlovo	CBP IN-VIVO TRANSCRIPTIONAL COACTIVATOR DIFFERENTIATION COMPLEX BOMBYX-MORI BMFTZ-F1 SILKWORM GENE-EXPRESSION BINDING PROTEIN
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[27876AC7DC0E]
http://linked.open...i/riv/nazevZdroje	Development
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Functions and genetic interactions of a novel transcriptional coactivator and a nuclear receptor in drosophila and C. elegans development
http://linked.open...UplatneniVysledku	2003
http://linked.open...v/svazekPeriodika	130
http://linked.open...iv/tvurceVysledku	Jindra, Marek Ueda, H. Liu, Q. Hirose, S. Hiromi, Y.
http://linked.open...n/vavai/riv/zamer	The use of insects for quality assessment and possible management of the ecosystems in Central Europe
issn	0950-1991
number of pages	10 (xsd:int)
http://localhost/t...ganizacniJednotka	12310

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