About: Sporadic incidence of factor XI deficiency in Holstein cattle

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Factor XI (FIX) is a plasma serine protease involved in the early activation of the blood coagulation cascade. A survey of Holstein cattle, and Czech Simmental cattle crossed with Holstein, was done to determine whether animals heterozygous for FXI deficiency were present. Mutations in exon 12 and exon 9 were analysed. The method used was based on the polymerase chain reaction and subsequent distinction of the lenght of fragments.In the panel analysed (279 Holstein and 30 Simmentals), one heterozygous carrier of the recessive allele in exon 12 ( a German Holstein cow) was found. Some authors have found that the frequency is high in some breeding lines and low in others. Evidently the lines in our änalysis are part of the group with a low frequency. In exon 9, all the animals (100 Holstein and 52 Simmentals) were honozygous wild type. To date, the mutation in exon 9 has been found only in Japanese black cattle, and its breed-specific occurrence was therefore not disconfirmed by our assay. Our result Factor XI (FIX) is a plasma serine protease involved in the early activation of the blood coagulation cascade. A survey of Holstein cattle, and Czech Simmental cattle crossed with Holstein, was done to determine whether animals heterozygous for FXI deficiency were present. Mutations in exon 12 and exon 9 were analysed. The method used was based on the polymerase chain reaction and subsequent distinction of the lenght of fragments.In the panel analysed (279 Holstein and 30 Simmentals), one heterozygous carrier of the recessive allele in exon 12 ( a German Holstein cow) was found. Some authors have found that the frequency is high in some breeding lines and low in others. Evidently the lines in our änalysis are part of the group with a low frequency. In exon 9, all the animals (100 Holstein and 52 Simmentals) were honozygous wild type. To date, the mutation in exon 9 has been found only in Japanese black cattle, and its breed-specific occurrence was therefore not disconfirmed by our assay. Our result (en) Faktor XI (FIX) je plazmová serinová proteáza, zahrnutá do časné aktivace kaskády krevní srážlivosti. Byl proveden průzkum u holštýnského skotu a kříženců českého strakatého skotu s holštýnským skotem s cílem stanovit, zda se zde vyskytují heterozygoti rpo deficiency FXI (cs)
Title	Sporadic incidence of factor XI deficiency in Holstein cattle Ojedinělý výskyt deficience faktoru XI u holštýnského skotu (cs) Sporadic incidence of factor XI deficiency in Holstein cattle (en)
skos:prefLabel	Sporadic incidence of factor XI deficiency in Holstein cattle Ojedinělý výskyt deficience faktoru XI u holštýnského skotu (cs) Sporadic incidence of factor XI deficiency in Holstein cattle (en)
skos:notation	RIV/60076658:12220/08:00009544!RIV09-MZE-12220___
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(QF3012), S, Z(MSM6007665806)
http://linked.open...iv/cisloPeriodika	12
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Čítek, Jindřich Řehout, Václav Hanusová, Lenka
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Jihočeská univerzita v Českých Budějovicích / Zemědělská fakulta
http://linked.open...dnocenehoVysledku	396628
http://linked.open...ai/riv/idVysledku	RIV/60076658:12220/08:00009544
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Holstein; factor XI; exon 12; exon 9; PCR (en)
http://linked.open.../riv/klicoveSlovo	PCR exon 12 exon 9 factor XI Holstein
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[09CDD3EF43B1]
http://linked.open...i/riv/nazevZdroje	JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
http://linked.open...in/vavai/riv/obor	GJ
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Inherited Diseases of Cattle
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	88
http://linked.open...iv/tvurceVysledku	Hanusová, Lenka Čítek, Jindřich Řehout, Václav Vrabcová, P.
http://linked.open...ain/vavai/riv/wos	000262541700002
http://linked.open...n/vavai/riv/zamer	Sustainable methods of agricultural management in montane and submontane areas with respect to harmonization of the production and nonproduction spheres
issn	0022-5142
number of pages	4 (xsd:int)
http://localhost/t...ganizacniJednotka	12220

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