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  • Přehledný článek věnovaný pokrokům v chronohematologii v posledních letech. Jsou nastoleny otázky týkající se hematoimunitního systému, jeho regulace na urovni celého organismu i na úrovn aktivity genů. Problematika regulace biorytmů při hemokoagulaci a fibrinolýze zůstává stále ve velké míře neobjasněna. Endogenní složka rytmů usnadňuje reparativní procesy během subjektivní noci. (cs)
  • The circadian rhythms of the haemato-immune system seem to be synchronized by two clocks: the hypothalamic endogenous, and the exogenous which is based on environmental stimuli. The suprachiasmatic nucleus is not only a circadian clock, it also synchronizes peripheral oscillators and integrates light information through the retino-hypothalamic tract. The role of the ?peripheral? clock genes in mature leucocytes still remains an unanswered question as well as the role of clock proteins in ?non-clock? physiology. The circadian rhythms may be a basis for circannual variations, although the molecular bases of such rhythms remain a mystery. There are several hormones which have a significant impact on haematological characteristics; the finding of a lower superoxide release from granulocytes at higher melatonin levels opens up new research opportunities for melatonin therapy. Discrepancies between circadian changes in mRNAs and the appropriate protein participating in haemocoagulation and fibrinolysis may
  • The circadian rhythms of the haemato-immune system seem to be synchronized by two clocks: the hypothalamic endogenous, and the exogenous which is based on environmental stimuli. The suprachiasmatic nucleus is not only a circadian clock, it also synchronizes peripheral oscillators and integrates light information through the retino-hypothalamic tract. The role of the ?peripheral? clock genes in mature leucocytes still remains an unanswered question as well as the role of clock proteins in ?non-clock? physiology. The circadian rhythms may be a basis for circannual variations, although the molecular bases of such rhythms remain a mystery. There are several hormones which have a significant impact on haematological characteristics; the finding of a lower superoxide release from granulocytes at higher melatonin levels opens up new research opportunities for melatonin therapy. Discrepancies between circadian changes in mRNAs and the appropriate protein participating in haemocoagulation and fibrinolysis may (en)
Title
  • Advances in chronohaematology
  • Advances in chronohaematology (en)
  • Pokroky v chronohematologii (cs)
skos:prefLabel
  • Advances in chronohaematology
  • Advances in chronohaematology (en)
  • Pokroky v chronohematologii (cs)
skos:notation
  • RIV/60076658:12110/08:00009098!RIV09-MSM-12110___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • V
http://linked.open...iv/cisloPeriodika
  • 2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 355012
http://linked.open...ai/riv/idVysledku
  • RIV/60076658:12110/08:00009098
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • circadian; seasonal; clock gene; haemostasis; immunity; melatonin; superoxide (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • CZ - Česká republika
http://linked.open...ontrolniKodProRIV
  • [DF65E0C6D546]
http://linked.open...i/riv/nazevZdroje
  • Journal of Applied Biomedicine
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 6
http://linked.open...iv/tvurceVysledku
  • Berger, Josef
issn
  • 1214-021X
number of pages
http://localhost/t...ganizacniJednotka
  • 12110
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