About: Analysis of urinary 8-hydroxy-2´-deoxyguanosine by high-performance liquid chromatography with electrochemical detection

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About: Analysis of urinary 8-hydroxy-2´-deoxyguanosine by high-performance liquid chromatography with electrochemical detection Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	8-hydroxy-2’-deoxyguanosine (8-OH-2’-dG) is one of the predominant forms of radical-induced lesions to DNA, and therefore it has been widely used as a biomarker for oxidative stress. We studied an analytical procedure of determination of urinary 8-OH-2’-dG. A routine assay of free 8-OH-2’-dG in body fluids such as urine is problematic, therefore the purification of this adduct from urine employs solid-phase extraction (SPE) procedure. Various SPE columns from different producers were used as follows: Waters – Oasis MCX (sorbent silica + benzensulfonic acid), Supelco Discovery C18 Oktadecyl (sorbent silica + C18), UCT Columns – Clean Screen DAU206 (sorbent silica + C18 + benzenculfonic acid) and Styre Screen DBX (sorbent styrene-divinylbenzene + C18 + benzensulfonic acid), Macherey-Nagel Chromabond HR-X (sorbent styrene-divinylbenzene) and HR-X-C (sorbent styrene-divinylbenzene + benzensulfonic acid), Phenomenex STRATA X-C (sorbent styrene-divinylbenzene + benzensulfonic acid). 8-hydroxy-2’-deoxyguanosine (8-OH-2’-dG) is one of the predominant forms of radical-induced lesions to DNA, and therefore it has been widely used as a biomarker for oxidative stress. We studied an analytical procedure of determination of urinary 8-OH-2’-dG. A routine assay of free 8-OH-2’-dG in body fluids such as urine is problematic, therefore the purification of this adduct from urine employs solid-phase extraction (SPE) procedure. Various SPE columns from different producers were used as follows: Waters – Oasis MCX (sorbent silica + benzensulfonic acid), Supelco Discovery C18 Oktadecyl (sorbent silica + C18), UCT Columns – Clean Screen DAU206 (sorbent silica + C18 + benzenculfonic acid) and Styre Screen DBX (sorbent styrene-divinylbenzene + C18 + benzensulfonic acid), Macherey-Nagel Chromabond HR-X (sorbent styrene-divinylbenzene) and HR-X-C (sorbent styrene-divinylbenzene + benzensulfonic acid), Phenomenex STRATA X-C (sorbent styrene-divinylbenzene + benzensulfonic acid). (en)
Title	Analysis of urinary 8-hydroxy-2´-deoxyguanosine by high-performance liquid chromatography with electrochemical detection Analysis of urinary 8-hydroxy-2´-deoxyguanosine by high-performance liquid chromatography with electrochemical detection (en)
skos:prefLabel	Analysis of urinary 8-hydroxy-2´-deoxyguanosine by high-performance liquid chromatography with electrochemical detection Analysis of urinary 8-hydroxy-2´-deoxyguanosine by high-performance liquid chromatography with electrochemical detection (en)
skos:notation	RIV/49813994:_____/09:#0000016!RIV10-AV0-49813994
http://linked.open...avai/riv/aktivita	P S
http://linked.open...avai/riv/aktivity	P(KAN208130801), S
http://linked.open...vai/riv/dodaniDat	2010
http://linked.open...aciTvurceVysledku	Kašparová, Terezie Jelínková, Iva Horna, Aleš Zítka, Ondřej
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	RADANAL s.r.o.
http://linked.open...dnocenehoVysledku	302974
http://linked.open...ai/riv/idVysledku	RIV/49813994:_____/09:#0000016
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	8-hydroxy-2´-deoxyguanosine; DNA damage; HPLC-EC (en)
http://linked.open.../riv/klicoveSlovo	DNA damage HPLC-EC 8-hydroxy-2´-deoxyguanosine
http://linked.open...ontrolniKodProRIV	[E663CB453EF1]
http://linked.open...v/mistoKonaniAkce	Brno
http://linked.open...i/riv/mistoVydani	nám. T. G. Masaryka 5555, 760 01 Zlín
http://linked.open...i/riv/nazevZdroje	International Conference VITAMINS, NUTRITION, DIAGNOSTIC Brno, Czech Republic, August 31 - September 2, 2009 The Abstract Book
http://linked.open...in/vavai/riv/obor	CG
http://linked.open...ichTvurcuVysledku	4 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	New design and exploiting nanobiosensors and nanosensors to target medicine (NANOSEMED)
http://linked.open...UplatneniVysledku	2009
http://linked.open...iv/tvurceVysledku	Adam, Vojtěch Horna, Aleš Jelínková, Iva Kizek, René Zítka, Ondřej Kašparová, Terezie
http://linked.open...vavai/riv/typAkce	WRD - Světová
http://linked.open.../riv/zahajeniAkce	2009-08-31 (xsd:date)
number of pages	2 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Univerzita Tomáše Bati ve Zlíně
https://schema.org/isbn	978-80-7318-809-2

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