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Description
  • Bariérová funkce pokožky má význam pro přísun léčiv i pro odhad rizika při zasažení kůže různými chemikáliemi. Hodnocení permeability všech nově syntetizovaných látek nemůže vycházet pouze z experimentů in vivo. Počítačové modelování a QSAR metody poskytují málo nákladný a rychlý způsob odhadu potenciálu permeability kůže pro látky určité struktury ještě před jejich syntézou a umožňují stanovení prioritních struktur pro testování in vitro a in vivo. Pro ilustraci výpočtových metod k odhadu permeability sloučenin kůží byly zvoleny kongenerické série triterpenů. (cs)
  • The skin barrier is important both to the topical delivery of drugs and to risk assessment following dermal exposure to various chemicals. It is impossible to assess the skin permeability of all new molecules synthesized in laboratory using only in vivo experiments. Computational modeling and QSAR methods provide an inexpensive and fast way to assess the potential for skin permeability of molecule before synthesis and enables prioritization of molekules for in vitro and in vivo tests. To illustrate the possibility of the use of calculation methods to estimate the skin permeability of compounds a congeneric series of triterpenes was chosen.
  • The skin barrier is important both to the topical delivery of drugs and to risk assessment following dermal exposure to various chemicals. It is impossible to assess the skin permeability of all new molecules synthesized in laboratory using only in vivo experiments. Computational modeling and QSAR methods provide an inexpensive and fast way to assess the potential for skin permeability of molecule before synthesis and enables prioritization of molekules for in vitro and in vivo tests. To illustrate the possibility of the use of calculation methods to estimate the skin permeability of compounds a congeneric series of triterpenes was chosen. (en)
Title
  • Structure correlated parameters and their influence on the bioactivity of compounds
  • Structure correlated parameters and their influence on the bioactivity of compounds (en)
  • Strukturní korelační parametry a jejich vliv na bioaktivitu sloučenin (cs)
skos:prefLabel
  • Structure correlated parameters and their influence on the bioactivity of compounds
  • Structure correlated parameters and their influence on the bioactivity of compounds (en)
  • Strukturní korelační parametry a jejich vliv na bioaktivitu sloučenin (cs)
skos:notation
  • RIV/49777513:23420/08:00500832!RIV09-MSM-23420___
http://linked.open...avai/riv/aktivita
http://linked.open...avai/riv/aktivity
  • S
http://linked.open...iv/cisloPeriodika
  • 1-2
http://linked.open...vai/riv/dodaniDat
http://linked.open...aciTvurceVysledku
http://linked.open.../riv/druhVysledku
http://linked.open...iv/duvernostUdaju
http://linked.open...titaPredkladatele
http://linked.open...dnocenehoVysledku
  • 397827
http://linked.open...ai/riv/idVysledku
  • RIV/49777513:23420/08:00500832
http://linked.open...riv/jazykVysledku
http://linked.open.../riv/klicovaSlova
  • skin permeability; structure-activity; triterpenes (en)
http://linked.open.../riv/klicoveSlovo
http://linked.open...odStatuVydavatele
  • PL - Polská republika
http://linked.open...ontrolniKodProRIV
  • [D86FC28AEBEF]
http://linked.open...i/riv/nazevZdroje
  • Polish Journal of Chemistry
http://linked.open...in/vavai/riv/obor
http://linked.open...ichTvurcuVysledku
http://linked.open...cetTvurcuVysledku
http://linked.open...UplatneniVysledku
http://linked.open...v/svazekPeriodika
  • 82
http://linked.open...iv/tvurceVysledku
  • Kraitr, Milan
  • Richtr, Václav
  • Persona, Marek
  • Gęca, Tomasz
  • Persona, Andrzej
http://linked.open...ain/vavai/riv/wos
  • 000254034800031
issn
  • 0137-5083
number of pages
http://localhost/t...ganizacniJednotka
  • 23420
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