About: Design of Polycaprolactone Vascular Grafts

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Design of Polycaprolactone Vascular Grafts Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://jit.sagepub.com/content/early/2014/06/23/1528083714540701.full.pdf+html
Description	A large number of patients suffer from vascular diseases, resulting in the need for bypass surgery. Since there are still limitations in the replacement of small diameter vascular grafts, the need and demand for developing more desirable grafts is increasing day by day. In this study, polycaprolactone small-diameter (6 mm) vascular grafts were produced successfully using custom-designed electrospinning apparatus. Radial fiber orientation was achieved by increasing the rotational speed of the collector. The morphological, structural, mechanical, and biological properties were examined. The results show that oriented scaffolds with 2 µm average fiber diameter provide 1 MPa ultimate tensile strength in the radial direction. The pore size area was found to be adequate in the oriented samples required for cell proliferation and diffusion through the tunica media. In vitro biocompatibility of the grafts was proven with 3T3 mouse fibroblasts. After cell seeding, the oriented fibers serve as a cue for radial cell alignment. An understanding of electrospun material parameters together with knowledge of native blood vessel structures and properties is a considerable part in designing small-diameter vascular grafts. A large number of patients suffer from vascular diseases, resulting in the need for bypass surgery. Since there are still limitations in the replacement of small diameter vascular grafts, the need and demand for developing more desirable grafts is increasing day by day. In this study, polycaprolactone small-diameter (6 mm) vascular grafts were produced successfully using custom-designed electrospinning apparatus. Radial fiber orientation was achieved by increasing the rotational speed of the collector. The morphological, structural, mechanical, and biological properties were examined. The results show that oriented scaffolds with 2 µm average fiber diameter provide 1 MPa ultimate tensile strength in the radial direction. The pore size area was found to be adequate in the oriented samples required for cell proliferation and diffusion through the tunica media. In vitro biocompatibility of the grafts was proven with 3T3 mouse fibroblasts. After cell seeding, the oriented fibers serve as a cue for radial cell alignment. An understanding of electrospun material parameters together with knowledge of native blood vessel structures and properties is a considerable part in designing small-diameter vascular grafts. (en)
Title	Design of Polycaprolactone Vascular Grafts Design of Polycaprolactone Vascular Grafts (en)
skos:prefLabel	Design of Polycaprolactone Vascular Grafts Design of Polycaprolactone Vascular Grafts (en)
skos:notation	RIV/46747885:24410/14:#0003928!RIV15-MSM-24410___
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(ED3.1.00/14.0306)
http://linked.open...iv/cisloPeriodika	June
http://linked.open...vai/riv/dodaniDat	2015
http://linked.open...aciTvurceVysledku	Lukáš, David Mikeš, Petr Horáková, Jana
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Technická univerzita v Liberci / Fakulta textilní
http://linked.open...dnocenehoVysledku	10488
http://linked.open...ai/riv/idVysledku	RIV/46747885:24410/14:#0003928
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Vascular graft; polycaprolactone; electrospinning (en)
http://linked.open.../riv/klicoveSlovo	polycaprolactone electrospinning Vascular graft
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[BDC4A1C35519]
http://linked.open...i/riv/nazevZdroje	Journal of Industrial Textiles
http://linked.open...in/vavai/riv/obor	FP
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	6 (xsd:int)
http://linked.open...vavai/riv/projekt	Innovative products and environmental technologies
http://linked.open...UplatneniVysledku	2014
http://linked.open...iv/tvurceVysledku	Horáková, Jana Mikeš, Petr Lukáš, David Yalcin, I. Domín, R. Sadikoglu, T.
issn	1530-8057
number of pages	21 (xsd:int)
http://bibframe.org/vocab/doi	10.1177/1528083714540701
http://localhost/t...ganizacniJednotka	24410

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 48 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software