About: Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Flavonoids represent a group of phytochemicals exhibiting a wide range of biological activities arising mainly from their antioxidant properties and ability to modulate several enzymes or cell receptors. Flavonoids have been recognized to exert anti-bacterial and anti-viral activity, anti-inflammatory, anti-angionic, analgesic, anti-allrgic effects, hepatoprotective. However, not all flavonoidsand their actions are necessarily beneficial. Some flavonoids have mutagenic and/or prooxidant effects and can also interfere with essential biochemical pathways. Among the proteins that interact with flavonoids, cytochromes P450 (CYPs), monooxygenases metabolizing xenobiotics and endogenous substrates, play a promonent role. Flavonoid compouds influence these enzymes in several ways:flavonoids induce the expression of several CYPs and modulate their metabolic activity. In addition, some CYPs participatein metabolism of flavonoids. Flavonoids enhance activation of carcinogens and/or influence the metabolism of d Flavonoids represent a group of phytochemicals exhibiting a wide range of biological activities arising mainly from their antioxidant properties and ability to modulate several enzymes or cell receptors. Flavonoids have been recognized to exert anti-bacterial and anti-viral activity, anti-inflammatory, anti-angionic, analgesic, anti-allrgic effects, hepatoprotective. However, not all flavonoidsand their actions are necessarily beneficial. Some flavonoids have mutagenic and/or prooxidant effects and can also interfere with essential biochemical pathways. Among the proteins that interact with flavonoids, cytochromes P450 (CYPs), monooxygenases metabolizing xenobiotics and endogenous substrates, play a promonent role. Flavonoid compouds influence these enzymes in several ways:flavonoids induce the expression of several CYPs and modulate their metabolic activity. In addition, some CYPs participatein metabolism of flavonoids. Flavonoids enhance activation of carcinogens and/or influence the metabolism of d (en)
Title	Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450 Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450 (en)
skos:prefLabel	Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450 Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450 (en)
skos:notation	RIV/46356606:_____/02:00006664!RIV/2004/GA0/BIOPH4/N
http://linked.open.../vavai/riv/strany	1-21
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(GA523/01/0840), Z(MSM 113100001)
http://linked.open...iv/cisloPeriodika	January
http://linked.open...vai/riv/dodaniDat	2004
http://linked.open...aciTvurceVysledku	Trefil, Pavel
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	BIOPHARM, Výzkumný ústav biofarmacie a veterinárních léčiv a.s.
http://linked.open...dnocenehoVysledku	646305
http://linked.open...ai/riv/idVysledku	RIV/46356606:_____/02:00006664
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Flavonoids, Cytochrome P450, Induction, Inhibition, Aromatase, Cancer (en)
http://linked.open.../riv/klicoveSlovo	Cancer Inhibition Aromatase Induction Cytochrome P450 Flavonoids
http://linked.open...odStatuVydavatele	IE - Irsko
http://linked.open...ontrolniKodProRIV	[517E8FB57B23]
http://linked.open...i/riv/nazevZdroje	Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450
http://linked.open...in/vavai/riv/obor	EI
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	3 (xsd:int)
http://linked.open...ocetUcastnikuAkce	0 (xsd:int)
http://linked.open...nichUcastnikuAkce	0 (xsd:int)
http://linked.open...vavai/riv/projekt	Study of the possible increase of poultry productivity by modulation of cytochrome P450 expression and activity during chicken embryonic and postemb
http://linked.open...UplatneniVysledku	2002
http://linked.open...v/svazekPeriodika	139
http://linked.open...iv/tvurceVysledku	Trefil, Pavel
http://linked.open...n/vavai/riv/zamer	http://linked.opendata.cz/resource/domain/vavai/zamer/MSM%20113100001
issn	0009-2797
number of pages	21 (xsd:int)

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