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rdf:type
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Description
| - Byla určena protisrážlivá aktivita etanolového extraktu Leuzea carthamoides. (cs)
- Plants and their secondary metabolites, including flavonoids, exhibit a wide range of biological effects. Consequently, natural substances are receiving an increased attention in medicinal research. Owing to these facts, in vitro antiplatelet activity of ethanol summary extract and four flavonoids from Leuzea carthamoides was determined in human platelet-rich plasma. Arachidonic acid, adenosine diphosphate, collagen, and thrombin were used as agonists of platelet aggregation. The summary extract showed a significant inhibition of the aggregation induced by and ADP. Of the tested flavonoids, eriodictyol and patuletin influenced COL and AA-induced aggregation. Their IC50 values are presented. Flavonoid glycosides eriodictyol-7-glucopyranoside and 6-hydroxykaempferol-7-O-(6-O-acetyl-Dsmall cap-glucopyranoside) were found to be weak antiplatelet agents. These results confirmed the fact that glucosylation decreases the antiplatelet activity. Quantitative composition of tested flavonoids in L. carthamoides
- Plants and their secondary metabolites, including flavonoids, exhibit a wide range of biological effects. Consequently, natural substances are receiving an increased attention in medicinal research. Owing to these facts, in vitro antiplatelet activity of ethanol summary extract and four flavonoids from Leuzea carthamoides was determined in human platelet-rich plasma. Arachidonic acid, adenosine diphosphate, collagen, and thrombin were used as agonists of platelet aggregation. The summary extract showed a significant inhibition of the aggregation induced by and ADP. Of the tested flavonoids, eriodictyol and patuletin influenced COL and AA-induced aggregation. Their IC50 values are presented. Flavonoid glycosides eriodictyol-7-glucopyranoside and 6-hydroxykaempferol-7-O-(6-O-acetyl-Dsmall cap-glucopyranoside) were found to be weak antiplatelet agents. These results confirmed the fact that glucosylation decreases the antiplatelet activity. Quantitative composition of tested flavonoids in L. carthamoides (en)
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Title
| - In vitro antiplatelet activity of flavonoids from Leuzea carthamoides
- In vitro antiplatelet activity of flavonoids from Leuzea carthamoides (en)
- In vitro protisrážlivá aktivita flavonoidů Leuzea carthamoides (cs)
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skos:prefLabel
| - In vitro antiplatelet activity of flavonoids from Leuzea carthamoides
- In vitro antiplatelet activity of flavonoids from Leuzea carthamoides (en)
- In vitro protisrážlivá aktivita flavonoidů Leuzea carthamoides (cs)
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skos:notation
| - RIV/44555601:13440/08:00004241!RIV09-MSM-13440___
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/44555601:13440/08:00004241
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Antiplatelet activity; Flavonoids; Leuzea carthamoides; Aggregation; Plants; Quantity. (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
| - Drug & Chemical Toxicology
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Kuča, Kamil
- Opletal, L.
- Kolečkář, V.
- Červenka, F.
- Řeháková, Z.
- Jůn, D.
- Kubiková, K.
- Brojerová, E.
- Hronek, M.
- Opletalová, V.
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issn
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number of pages
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http://localhost/t...ganizacniJednotka
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