About: Photodynamic inactivation of prions by disulfonated hydroxyaluminium phthalocyanine

Facets (new session)
Description
Metadata
Settings
- owl:sameAs
- Inference Rule:

About: Photodynamic inactivation of prions by disulfonated hydroxyaluminium phthalocyanine Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
rdfs:seeAlso	http://vir.sgmjournals.org/content/93/Pt_11/2512.full.pdf+html
Description	Sulfonated phthalocyanines (Pcs) are cyclic tetrapyrroles that constitute a group of photosensitizers. In the presence of visible light and diatomic oxygen, Pcs produce singlet oxygen and other reactive oxygen species that have known degradation effects on lipids, proteins and/or nucleic acids. Pcs have been used successfully in the treatment of bacterial, yeast and fungal infections, but their use in the photodynamic inactivation of prions has never been reported. Here, we evaluated the photodynamic activity of the disodium salt of disulfonated hydroxyaluminium phthalocyanine (PcDS) against mouse-adapted scrapie RML prions in vitro. PcDS treatment of RML brain homogenate resulted in a time- and dose-dependent inactivation of prions. The photodynamic potential of Pcs offers a new way to inactivate prions using biodegradable compounds at room temperature and normal pressure, which could be useful for treating thermolabile materials and liquids. Sulfonated phthalocyanines (Pcs) are cyclic tetrapyrroles that constitute a group of photosensitizers. In the presence of visible light and diatomic oxygen, Pcs produce singlet oxygen and other reactive oxygen species that have known degradation effects on lipids, proteins and/or nucleic acids. Pcs have been used successfully in the treatment of bacterial, yeast and fungal infections, but their use in the photodynamic inactivation of prions has never been reported. Here, we evaluated the photodynamic activity of the disodium salt of disulfonated hydroxyaluminium phthalocyanine (PcDS) against mouse-adapted scrapie RML prions in vitro. PcDS treatment of RML brain homogenate resulted in a time- and dose-dependent inactivation of prions. The photodynamic potential of Pcs offers a new way to inactivate prions using biodegradable compounds at room temperature and normal pressure, which could be useful for treating thermolabile materials and liquids. (en)
Title	Photodynamic inactivation of prions by disulfonated hydroxyaluminium phthalocyanine Photodynamic inactivation of prions by disulfonated hydroxyaluminium phthalocyanine (en)
skos:prefLabel	Photodynamic inactivation of prions by disulfonated hydroxyaluminium phthalocyanine Photodynamic inactivation of prions by disulfonated hydroxyaluminium phthalocyanine (en)
skos:notation	RIV/28778758:_____/12:#0000047!RIV14-MPO-28778758
http://linked.open...avai/riv/aktivita	N P
http://linked.open...avai/riv/aktivity	N, P(GA310/08/0878), P(GP310/09/P260)
http://linked.open...iv/cisloPeriodika	11
http://linked.open...vai/riv/dodaniDat	2014
http://linked.open...aciTvurceVysledku	Rakušan, Jan Karásková, Marie
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Centrum organické chemie s.r.o.
http://linked.open...dnocenehoVysledku	158550
http://linked.open...ai/riv/idVysledku	RIV/28778758:_____/12:#0000047
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	sulfonated phthalocyanines; prion inactivation (en)
http://linked.open.../riv/klicoveSlovo	prion inactivation sulfonated phthalocyanines
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[FD6E016B3419]
http://linked.open...i/riv/nazevZdroje	Journal of General Virology
http://linked.open...in/vavai/riv/obor	EE
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Cell culture for propagation of prions: influence of cell culture proliferation and expression of endogenous retroviruses The role of cellular prion protein in erythroid differentiation: possible link to peripheral pathogenesis of prion diseases
http://linked.open...UplatneniVysledku	2012
http://linked.open...v/svazekPeriodika	93
http://linked.open...iv/tvurceVysledku	Karásková, Marie Rakušan, Jan
http://linked.open...ain/vavai/riv/wos	000310819600024
issn	0022-1317
number of pages	6 (xsd:int)
http://bibframe.org/vocab/doi	10.1099/vir.0.044727-0

Faceted Search & Find service v1.16.118 as of Jun 21 2024

Alternative Linked Data Documents: ODE Content Formats:

RDF

ODATA

Microdata

About

OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 59 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software