About: The cell damage and regeneration in the immature brain and glioma cultures irradiated by epithermal neutron beam of the LVR-15 nuclear reactor in Řež

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About: The cell damage and regeneration in the immature brain and glioma cultures irradiated by epithermal neutron beam of the LVR-15 nuclear reactor in Řež Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Interaction of epithermal neutrons with boron-10 (10B) leads to a damage of tumor tissue conferred (circumscribed) even soliatary cells. The nuclear reactors used for tumor therapy (Boron-Neutron-Capture-Therapy, BNCT) require individual tuning and monitoring by physical and biological methods. Here, were report effects of epithermal beam of the LVR-15 in Řež (7.8x 108n/cm2, 9 MW, 16.1 cGy/min) on the immature rat brain and C6 glioma culture, the model developed by us for this purpose (Mares et al. 1997, Burian et al. Kagawa). Irradiation of animals for 4 to 7 minutes induced the dose- and the cell differentiation degree- dependent apoptosis-like death in the cerebellum and forebrain, exceeding 2.1 times a gamma radiation equivalent. 3 days later, a dose inverse regeneration was evident in the cerebellum. In cultures irradiated for 30 to 45 min, the cells slowed-down cycling and cell death reaching a peak value at 72 to 96 h. Interaction of epithermal neutrons with boron-10 (10B) leads to a damage of tumor tissue conferred (circumscribed) even soliatary cells. The nuclear reactors used for tumor therapy (Boron-Neutron-Capture-Therapy, BNCT) require individual tuning and monitoring by physical and biological methods. Here, were report effects of epithermal beam of the LVR-15 in Řež (7.8x 108n/cm2, 9 MW, 16.1 cGy/min) on the immature rat brain and C6 glioma culture, the model developed by us for this purpose (Mares et al. 1997, Burian et al. Kagawa). Irradiation of animals for 4 to 7 minutes induced the dose- and the cell differentiation degree- dependent apoptosis-like death in the cerebellum and forebrain, exceeding 2.1 times a gamma radiation equivalent. 3 days later, a dose inverse regeneration was evident in the cerebellum. In cultures irradiated for 30 to 45 min, the cells slowed-down cycling and cell death reaching a peak value at 72 to 96 h. (en)
Title	The cell damage and regeneration in the immature brain and glioma cultures irradiated by epithermal neutron beam of the LVR-15 nuclear reactor in Řež The cell damage and regeneration in the immature brain and glioma cultures irradiated by epithermal neutron beam of the LVR-15 nuclear reactor in Řež (en)
skos:prefLabel	The cell damage and regeneration in the immature brain and glioma cultures irradiated by epithermal neutron beam of the LVR-15 nuclear reactor in Řež The cell damage and regeneration in the immature brain and glioma cultures irradiated by epithermal neutron beam of the LVR-15 nuclear reactor in Řež (en)
skos:notation	RIV/26722445:_____/11:#0000651!RIV12-MPO-26722445
http://linked.open...avai/riv/aktivita	P
http://linked.open...avai/riv/aktivity	P(FR-TI1/378)
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Burian, Jiří Marek, Milan
http://linked.open.../riv/druhVysledku	D - Článek ve sborníku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Centrum výzkumu Řež s.r.o.
http://linked.open...dnocenehoVysledku	189372
http://linked.open...ai/riv/idVysledku	RIV/26722445:_____/11:#0000651
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Boron-Neutron-Capture-Therapy (en)
http://linked.open.../riv/klicoveSlovo	Boron-Neutron-Capture-Therapy
http://linked.open...ontrolniKodProRIV	[E11FCC4EE343]
http://linked.open...v/mistoKonaniAkce	Plzeň
http://linked.open...i/riv/mistoVydani	Plzeň
http://linked.open...i/riv/nazevZdroje	XX. Biologické dny : Kmenové buňky – od regenerativní medicíny k nádorové biologii
http://linked.open...in/vavai/riv/obor	BG
http://linked.open...ichTvurcuVysledku	2 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Application of neutron scattering in industry
http://linked.open...UplatneniVysledku	2011
http://linked.open...iv/tvurceVysledku	Burian, Jiří Marek, Milan
http://linked.open...vavai/riv/typAkce	CST - Celostátní
http://linked.open.../riv/zahajeniAkce	2011-01-01 (xsd:date)
number of pages	2 (xsd:int)
http://purl.org/ne...btex#hasPublisher	Československá biologická společnost a Lékařská fakulta UK v Plzni
https://schema.org/isbn	9788026008491

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