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| Description
| - A poster demonstrating the use of CE and chip CE in analysis of various molecular cancer markers Decisions in clinical oncology are growingly relying on modern tools and technologies coming from genome research. Currently, several treatment options are available to most patients suffering from common forms of solid cancers (e.g.colorectal, lung, pancreas ...). The clinical decision is taken based on the extent of the tumor defined by TNM (tumor, nodes, metastasis) or other types of staging. The treatment options usually include surgical removal of tumorous tissue, irradiation of the tumor, pharmacological chemotherapy or a combination thereof. Assessment of the disease prognosis is often the key component in the decision process. A number of molecular aberrations found in cancerous tissue such as DNA mutations, gene amplifications or DNA hypermethylation may be utilized as biomarkers defining the disease prognosis. Such molecular markers may also be used to predict the likelihood of a positive response towards a specific pharmacological therapy used to treat the tumor. At the same time, monitoring levels of circulating cell-free tumor DNA (cfDNA) in peripheral blood of cancer patients represents a vital tool for minimum-invasive follow-up of cancer patients. The presentation will demonstrate use of CE and chip CE in analysis of various molecular cancer genetic and epigenetic markers and its application in rational therapy selection, monitoring of the disease progression and assessment of its survival prognosis.
- A poster demonstrating the use of CE and chip CE in analysis of various molecular cancer markers Decisions in clinical oncology are growingly relying on modern tools and technologies coming from genome research. Currently, several treatment options are available to most patients suffering from common forms of solid cancers (e.g.colorectal, lung, pancreas ...). The clinical decision is taken based on the extent of the tumor defined by TNM (tumor, nodes, metastasis) or other types of staging. The treatment options usually include surgical removal of tumorous tissue, irradiation of the tumor, pharmacological chemotherapy or a combination thereof. Assessment of the disease prognosis is often the key component in the decision process. A number of molecular aberrations found in cancerous tissue such as DNA mutations, gene amplifications or DNA hypermethylation may be utilized as biomarkers defining the disease prognosis. Such molecular markers may also be used to predict the likelihood of a positive response towards a specific pharmacological therapy used to treat the tumor. At the same time, monitoring levels of circulating cell-free tumor DNA (cfDNA) in peripheral blood of cancer patients represents a vital tool for minimum-invasive follow-up of cancer patients. The presentation will demonstrate use of CE and chip CE in analysis of various molecular cancer genetic and epigenetic markers and its application in rational therapy selection, monitoring of the disease progression and assessment of its survival prognosis. (en)
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| Title
| - Applying CE and microchip CE to molecular cancer analysis: From research to clinical utility
- Applying CE and microchip CE to molecular cancer analysis: From research to clinical utility (en)
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| skos:prefLabel
| - Applying CE and microchip CE to molecular cancer analysis: From research to clinical utility
- Applying CE and microchip CE to molecular cancer analysis: From research to clinical utility (en)
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| skos:notation
| - RIV/26475821:_____/13:#0000193!RIV14-MZ0-26475821
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| http://linked.open...avai/riv/aktivita
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| http://linked.open...avai/riv/aktivity
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| http://linked.open...vai/riv/dodaniDat
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| http://linked.open...aciTvurceVysledku
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| http://linked.open.../riv/druhVysledku
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| http://linked.open...iv/duvernostUdaju
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| http://linked.open...titaPredkladatele
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| http://linked.open...dnocenehoVysledku
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| http://linked.open...ai/riv/idVysledku
| - RIV/26475821:_____/13:#0000193
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| http://linked.open...riv/jazykVysledku
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| http://linked.open.../riv/klicovaSlova
| - solid cancers, DNA hypermethylation, CE, microchip CE (en)
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| http://linked.open.../riv/klicoveSlovo
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| http://linked.open...ontrolniKodProRIV
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| http://linked.open...in/vavai/riv/obor
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| http://linked.open...ichTvurcuVysledku
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| http://linked.open...cetTvurcuVysledku
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| http://linked.open...vavai/riv/projekt
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| http://linked.open...UplatneniVysledku
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| http://linked.open...iv/tvurceVysledku
| - Belšánová, Barbora
- Benešová, Lucie
- Minárik, Marek
- Krajčová, Andrea
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